Reaction Details |
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Target | Tumor necrosis factor |
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Ligand | BDBM50373071 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEMBL_1751734 (CHEMBL4186494) |
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IC50 | 22000±n/a nM |
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Citation | Pandit, SS; Kulkarni, MR; Pandit, YB; Lad, NP; Khedkar, VM Synthesis and in vitro evaluations of 6-(hetero)-aryl-imidazo[1,2-b]pyridazine-3-sulfonamide's as an inhibitor of TNF-? production. Bioorg Med Chem Lett28:24-30 (2018) [PubMed] Article |
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More Info.: | Get all data from this article, Assay Method |
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Tumor necrosis factor |
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Name: | Tumor necrosis factor |
Synonyms: | Cachectin | TNF | TNF-a | TNF-alpha | TNFA | TNFA_HUMAN | TNFSF2 | Tumor necrosis factor (TNF-alpha) | Tumor necrosis factor (TNFa) | Tumor necrosis factor alpha (TNFα) | Tumor necrosis factor ligand superfamily member 2 | Tumor necrosis factor, membrane form | Tumor necrosis factor, soluble form | tumor necrosis factor alpha |
Type: | Enzyme |
Mol. Mass.: | 25645.11 |
Organism: | Homo sapiens (Human) |
Description: | P01375 |
Residue: | 233 |
Sequence: | MSTESMIRDVELAEEALPKKTGGPQGSRRCLFLSLFSFLIVAGATTLFCLLHFGVIGPQR
EEFPRDLSLISPLAQAVRSSSRTPSDKPVAHVVANPQAEGQLQWLNRRANALLANGVELR
DNQLVVPSEGLYLIYSQVLFKGQGCPSTHVLLTHTISRIAVSYQTKVNLLSAIKSPCQRE
TPEGAEAKPWYEPIYLGGVFQLEKGDRLSAEINRPDYLDFAESGQVYFGIIAL
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BDBM50373071 |
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n/a |
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Name | BDBM50373071 |
Synonyms: | CHEMBL255489 |
Type | Small organic molecule |
Emp. Form. | C32H32F3N3O2 |
Mol. Mass. | 547.6106 |
SMILES | CN(CCN(C)Cc1coc2cc(C)c(C)cc2c1=O)Cc1cn(-c2cccc(c2)C(F)(F)F)c2ccccc12 |
Structure |
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