| Reaction Details |
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 | Report a problem with these data |
| Target | Kappa-type opioid receptor |
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| Ligand | BDBM50454178 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_1752181 (CHEMBL4186941) |
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| Ki | 55±n/a nM |
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| Citation |  Fang, WJ; Murray, TF; Aldrich, JV Design, synthesis, and opioid activity of arodyn analogs cyclized by ring-closing metathesis involving Tyr(allyl). Bioorg Med Chem26:1157-1161 (2018) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Kappa-type opioid receptor |
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| Name: | Kappa-type opioid receptor |
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| Synonyms: | KOR-1 | Kappa Opioid Receptor | OPIATE Kappa | OPRK_RAT | Opioid receptor | Oprk1 | Ror-d |
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| Type: | G Protein-Coupled Receptor (GPCR) |
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| Mol. Mass.: | 42692.90 |
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| Organism: | Rattus norvegicus (rat) |
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| Description: | P34975 |
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| Residue: | 380 |
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| Sequence: | MESPIQIFRGEPGPTCAPSACLLPNSSSWFPNWAESDSNGSVGSEDQQLEPAHISPAIPV
IITAVYSVVFVVGLVGNSLVMFVIIRYTKMKTATNIYIFNLALADALVTTTMPFQSAVYL
MNSWPFGDVLCKIVISIDYYNMFTSIFTLTMMSVDRYIAVCHPVKALDFRTPLKAKIINI
CIWLLASSVGISAIVLGGTKVREDVDVIECSLQFPDDEYSWWDLFMKICVFVFAFVIPVL
IIIVCYTLMILRLKSVRLLSGSREKDRNLRRITKLVLVVVAVFIICWTPIHIFILVEALG
STSHSTAVLSSYYFCIALGYTNSSLNPVLYAFLDENFKRCFRDFCFPIKMRMERQSTNRV
RNTVQDPASMRDVGGMNKPV
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| BDBM50454178 |
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| n/a |
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| Name | BDBM50454178 |
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| Synonyms: | CHEMBL4214138 |
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| Type | Small organic molecule |
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| Emp. Form. | C80H125N25O14 |
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| Mol. Mass. | 1661.0076 |
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| SMILES | CC[C@H](C)[C@H](NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@@H]1Cc2ccc(OC\C=C\COc3ccc(C[C@H](NC(=O)[C@H](Cc4ccccc4)NC(C)=O)C(=O)N1)cc3)cc2)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCCCN)C(N)=O |r,t:57| |
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| Structure | 
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