| Reaction Details |
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 | Report a problem with these data |
| Target | Carbonic anhydrase 4 |
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| Ligand | BDBM50329823 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_1752586 (CHEMBL4187346) |
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| Kd | 5.7±n/a nM |
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| Citation |  ?apkauskait?, E; Zak?auskas, A; Ruibys, V; Linkuvien?, V; Paketuryt?, V; Gedgaudas, M; Kairys, V; Matulis, D Benzimidazole design, synthesis, and docking to build selective carbonic anhydrase VA inhibitors. Bioorg Med Chem26:675-687 (2018) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Carbonic anhydrase 4 |
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| Name: | Carbonic anhydrase 4 |
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| Synonyms: | CA-IV | CA4 | CAH4_HUMAN | Carbonate dehydratase IV | Carbonic anhydrase | Carbonic anhydrase 4 (CA IV) | Carbonic anhydrase IV (CA IV) |
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| Type: | Enzyme |
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| Mol. Mass.: | 35037.98 |
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| Organism: | Homo sapiens (Human) |
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| Description: | P22748 |
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| Residue: | 312 |
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| Sequence: | MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTK
AKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSD
LPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGF
QPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFRE
PIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLG
PMLACLLAGFLR
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| BDBM50329823 |
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| n/a |
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| Name | BDBM50329823 |
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| Synonyms: | 2-Chloro-5-[(2-ethyl-1H-benzimidazol-1-yl)acetyl]benzenesulfonamide | CHEMBL1272243 | N-alkylated benzimidazole derivative, 4e |
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| Type | Small organic molecule |
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| Emp. Form. | C17H16ClN3O3S |
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| Mol. Mass. | 377.845 |
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| SMILES | CCc1nc2ccccc2n1CC(=O)c1ccc(Cl)c(c1)S(N)(=O)=O |
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| Structure | 
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