| Reaction Details |
|---|
 | Report a problem with these data |
| Target | Plasminogen activator inhibitor 1 |
|---|
| Ligand | BDBM50454581 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | ChEMBL_1752854 (CHEMBL4187614) |
|---|
| IC50 | 3550±n/a nM |
|---|
| Citation |  Yamaoka, N; Murano, K; Kodama, H; Maeda, A; Dan, T; Nakabayashi, T; Miyata, T; Meguro, K Identification of novel plasminogen activator inhibitor-1 inhibitors with improved oral bioavailability: Structure optimization of N-acylanthranilic acid derivatives. Bioorg Med Chem Lett28:809-813 (2018) [PubMed] Article |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| Plasminogen activator inhibitor 1 |
|---|
| Name: | Plasminogen activator inhibitor 1 |
|---|
| Synonyms: | Endothelial plasminogen activator inhibitor | PAI | PAI-1 | PAI1 | PAI1_HUMAN | PLANH1 | Plasminogen activator inhibitor 1 | Plasminogen activator inhibitor 1 (PAI-1) | Plasminogen activator inhibitor-1 | Plasminogen activator-1 (PAI-1) | SERPINE1 |
|---|
| Type: | Enzyme |
|---|
| Mol. Mass.: | 45064.00 |
|---|
| Organism: | Homo sapiens (Human) |
|---|
| Description: | P05121 |
|---|
| Residue: | 402 |
|---|
| Sequence: | MQMSPALTCLVLGLALVFGEGSAVHHPPSYVAHLASDFGVRVFQQVAQASKDRNVVFSPY
GVASVLAMLQLTTGGETQQQIQAAMGFKIDDKGMAPALRHLYKELMGPWNKDEISTTDAI
FVQRDLKLVQGFMPHFFRLFRSTVKQVDFSEVERARFIINDWVKTHTKGMISNLLGKGAV
DQLTRLVLVNALYFNGQWKTPFPDSSTHRRLFHKSDGSTVSVPMMAQTNKFNYTEFTTPD
GHYYDILELPYHGDTLSMFIAAPYEKEVPLSALTNILSAQLISHWKGNMTRLPRLLVLPK
FSLETEVDLRKPLENLGMTDMFRQFQADFTSLSDQEPLHVAQALQKVKIEVNESGTVASS
STAVIVSARMAPEEIIMDRPFLFVVRHNPTGTVLFMGQVMEP
|
|
|
|---|
| BDBM50454581 |
|---|
| n/a |
|---|
| Name | BDBM50454581 |
|---|
| Synonyms: | CHEMBL4205472 |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C20H15ClN2O5 |
|---|
| Mol. Mass. | 398.797 |
|---|
| SMILES | OC(=O)c1cc(Cl)ccc1NC(=O)C(=O)NCc1cccc(c1)-c1ccoc1 |
|---|
| Structure | 
|
|---|
Search and Browse
