Reaction Details |
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Target | Plasminogen activator inhibitor 1 |
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Ligand | BDBM50454583 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEMBL_1752854 (CHEMBL4187614) |
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IC50 | 4740±n/a nM |
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Citation | Yamaoka, N; Murano, K; Kodama, H; Maeda, A; Dan, T; Nakabayashi, T; Miyata, T; Meguro, K Identification of novel plasminogen activator inhibitor-1 inhibitors with improved oral bioavailability: Structure optimization of N-acylanthranilic acid derivatives. Bioorg Med Chem Lett28:809-813 (2018) [PubMed] Article |
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More Info.: | Get all data from this article, Assay Method |
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Plasminogen activator inhibitor 1 |
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Name: | Plasminogen activator inhibitor 1 |
Synonyms: | Endothelial plasminogen activator inhibitor | PAI | PAI-1 | PAI1 | PAI1_HUMAN | PLANH1 | Plasminogen activator inhibitor 1 | Plasminogen activator inhibitor 1 (PAI-1) | Plasminogen activator inhibitor-1 | Plasminogen activator-1 (PAI-1) | SERPINE1 |
Type: | Enzyme |
Mol. Mass.: | 45064.00 |
Organism: | Homo sapiens (Human) |
Description: | P05121 |
Residue: | 402 |
Sequence: | MQMSPALTCLVLGLALVFGEGSAVHHPPSYVAHLASDFGVRVFQQVAQASKDRNVVFSPY
GVASVLAMLQLTTGGETQQQIQAAMGFKIDDKGMAPALRHLYKELMGPWNKDEISTTDAI
FVQRDLKLVQGFMPHFFRLFRSTVKQVDFSEVERARFIINDWVKTHTKGMISNLLGKGAV
DQLTRLVLVNALYFNGQWKTPFPDSSTHRRLFHKSDGSTVSVPMMAQTNKFNYTEFTTPD
GHYYDILELPYHGDTLSMFIAAPYEKEVPLSALTNILSAQLISHWKGNMTRLPRLLVLPK
FSLETEVDLRKPLENLGMTDMFRQFQADFTSLSDQEPLHVAQALQKVKIEVNESGTVASS
STAVIVSARMAPEEIIMDRPFLFVVRHNPTGTVLFMGQVMEP
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BDBM50454583 |
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n/a |
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Name | BDBM50454583 |
Synonyms: | CHEMBL4205996 |
Type | Small organic molecule |
Emp. Form. | C19H14ClNO5 |
Mol. Mass. | 371.771 |
SMILES | OC(=O)c1cc(Cl)ccc1NC(=O)COc1cccc(c1)-c1ccoc1 |
Structure |
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