| Reaction Details |
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 | Report a problem with these data |
| Target | 5-hydroxytryptamine receptor 1A |
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| Ligand | BDBM50005265 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_1318 (CHEMBL616695) |
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| Ki | 5125.0±n/a nM |
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| Citation |  Glennon, RA; Titeler, M; Lyon, RA; Slusher, RM N,N-di-n-propylserotonin: binding at serotonin binding sites and a comparison with 8-hydroxy-2-(di-n-propylamino)tetralin. J Med Chem31:867-70 (1988) [PubMed] |
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| More Info.: | Get all data from this article, Assay Method |
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| 5-hydroxytryptamine receptor 1A |
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| Name: | 5-hydroxytryptamine receptor 1A |
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| Synonyms: | 5-HT-1A | 5-HT1 | 5-HT1A | 5-Hydroxytryptamine receptor 1A (5-HT1A) | 5-hydroxytryptamine receptor 1A (5HT1A) | 5HT1A_RAT | 5ht1a | G-21 | Htr1a | Serotonin 1 (5-HT1) receptor | Serotonin 1a (5-HT1a) receptor/Adrenergic receptor alpha-1 | Serotonin receptor 1A |
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| Type: | G Protein-Coupled Receptor (GPCR) |
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| Mol. Mass.: | 46445.29 |
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| Organism: | Rattus norvegicus (rat) |
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| Description: | Binding assays were performed using rat hippocampal membranes. |
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| Residue: | 422 |
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| Sequence: | MDVFSFGQGNNTTASQEPFGTGGNVTSISDVTFSYQVITSLLLGTLIFCAVLGNACVVAA
IALERSLQNVANYLIGSLAVTDLMVSVLVLPMAALYQVLNKWTLGQVTCDLFIALDVLCC
TSSILHLCAIALDRYWAITDPIDYVNKRTPRRAAALISLTWLIGFLISIPPMLGWRTPED
RSDPDACTISKDHGYTIYSTFGAFYIPLLLMLVLYGRIFRAARFRIRKTVRKVEKKGAGT
SLGTSSAPPPKKSLNGQPGSGDWRRCAENRAVGTPCTNGAVRQGDDEATLEVIEVHRVGN
SKEHLPLPSESGSNSYAPACLERKNERNAEAKRKMALARERKTVKTLGIIMGTFILCWLP
FFIVALVLPFCESSCHMPALLGAIINWLGYSNSLLNPVIYAYFNKDFQNAFKKIIKCKFC
RR
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| BDBM50005265 |
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| n/a |
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| Name | BDBM50005265 |
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| Synonyms: | (+/-)2-(2,5-Dimethoxy-4-methyl-phenyl)-1-methyl-ethylamine | (-)2-(2,5-Dimethoxy-4-methyl-phenyl)-1-methyl-ethylamine | (Rec)2-(2,5-Dimethoxy-4-methyl-phenyl)-1-methyl-ethylamine; compound with 2-(2,5-dimethoxy-4-methyl-phenyl)-1-methyl-ethylamine | 2-(2,5-Dimethoxy-4-methyl-phenyl)-1-methyl-ethylamine | 2-(2,5-Dimethoxy-4-methyl-phenyl)-1-methyl-ethylamine((R)-(-)-DOM) | 2-(2,5-Dimethoxy-4-methyl-phenyl)-1-methyl-ethylamine(DOM) | CHEMBL8600 | DOM | DOM,R(-) | Racemic DOM |
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| Type | Small organic molecule |
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| Emp. Form. | C12H19NO2 |
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| Mol. Mass. | 209.2848 |
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| SMILES | COc1cc(CC(C)N)c(OC)cc1C |
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| Structure | 
|
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