| Reaction Details |
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 | Report a problem with these data |
| Target | Menin |
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| Ligand | BDBM50455879 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_1755017 (CHEMBL4189777) |
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| IC50 | 26±n/a nM |
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| Citation |  Borkin, D; Klossowski, S; Pollock, J; Miao, H; Linhares, BM; Kempinska, K; Jin, Z; Purohit, T; Wen, B; He, M; Sun, D; Cierpicki, T; Grembecka, J Complexity of Blocking Bivalent Protein-Protein Interactions: Development of a Highly Potent Inhibitor of the Menin-Mixed-Lineage Leukemia Interaction. J Med Chem61:4832-4850 (2018) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Menin |
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| Name: | Menin |
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| Synonyms: | MEN1 | MEN1_HUMAN | Menin/Histone-lysine N-methyltransferase MLL | SCG2 |
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| Type: | Protein |
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| Mol. Mass.: | 68022.55 |
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| Organism: | Homo sapiens (Human) |
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| Description: | O00255 |
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| Residue: | 610 |
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| Sequence: | MGLKAAQKTLFPLRSIDDVVRLFAAELGREEPDLVLLSLVLGFVEHFLAVNRVIPTNVPE
LTFQPSPAPDPPGGLTYFPVADLSIIAALYARFTAQIRGAVDLSLYPREGGVSSRELVKK
VSDVIWNSLSRSYFKDRAHIQSLFSFITGTKLDSSGVAFAVVGACQALGLRDVHLALSED
HAWVVFGPNGEQTAEVTWHGKGNEDRRGQTVNAGVAERSWLYLKGSYMRCDRKMEVAFMV
CAINPSIDLHTDSLELLQLQQKLLWLLYDLGHLERYPMALGNLADLEELEPTPGRPDPLT
LYHKGIASAKTYYRDEHIYPYMYLAGYHCRNRNVREALQAWADTATVIQDYNYCREDEEI
YKEFFEVANDVIPNLLKEAASLLEAGEERPGEQSQGTQSQGSALQDPECFAHLLRFYDGI
CKWEEGSPTPVLHVGWATFLVQSLGRFEGQVRQKVRIVSREAEAAEAEEPWGEEAREGRR
RGPRRESKPEEPPPPKKPALDKGLGTGQGAVSGPPRKPPGTVAGTARGPEGGSTAQVPAP
TASPPPEGPVLTFQSEKMKGMKELLVATKINSSAIKLQLTAQSQVQMKKQKVSTPSDYTL
SFLKRQRKGL
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| BDBM50455879 |
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| n/a |
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| Name | BDBM50455879 |
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| Synonyms: | CHEMBL4205576 |
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| Type | Small organic molecule |
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| Emp. Form. | C30H36F3N9O2S2 |
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| Mol. Mass. | 675.791 |
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| SMILES | Cc1c(CN2CCC(CC2)Nc2ncnc3sc(CC(F)(F)F)cc23)ccc2n(CCN3CCN(CC3)S(N)(=O)=O)c(cc12)C#N |
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| Structure | 
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