| Reaction Details |
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 | Report a problem with these data |
| Target | Adenosine receptor A2a/A2b |
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| Ligand | BDBM50021087 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_27751 (CHEMBL641987) |
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| Ki | 20±n/a nM |
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| Citation |  Jacobson, KA; Kirk, KL; Padgett, WL; Daly, JW Functionalized congeners of 1,3-dialkylxanthines: preparation of analogues with high affinity for adenosine receptors. J Med Chem28:1334-40 (1985) [PubMed] |
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| More Info.: | Get all data from this article, Assay Method |
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| Adenosine receptor A2a/A2b |
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| Name: | Adenosine receptor A2a/A2b |
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| Synonyms: | Adenosine A2 receptor |
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| Type: | n/a |
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| Mol. Mass.: | n/a |
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| Description: | ASSAY_ID of ChEMBL is 329906 |
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| Components: | This complex has 2 components. |
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| Component 1 |
| Name: | Adenosine receptor A2b |
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| Synonyms: | AA2BR_HUMAN | ADENOSINE A2B | ADORA2B | Adenosine receptor A2B (A2B) | Adenosine receptors A2b | Adenosine receptors; A2a & A2b |
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| Type: | G Protein-Coupled Receptor (GPCR) |
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| Mol. Mass.: | 36341.22 |
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| Organism: | Homo sapiens (Human) |
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| Description: | n/a |
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| Residue: | 332 |
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| Sequence: | MLLETQDALYVALELVIAALSVAGNVLVCAAVGTANTLQTPTNYFLVSLAAADVAVGLFA
IPFAITISLGFCTDFYGCLFLACFVLVLTQSSIFSLLAVAVDRYLAICVPLRYKSLVTGT
RARGVIAVLWVLAFGIGLTPFLGWNSKDSATNNCTEPWDGTTNESCCLVKCLFENVVPMS
YMVYFNFFGCVLPPLLIMLVIYIKIFLVACRQLQRTELMDHSRTTLQREIHAAKSLAMIV
GIFALCWLPVHAVNCVTLFQPAQGKNKPKWAMNMAILLSHANSVVNPIVYAYRNRDFRYT
FHKIISRYLLCQADVKSGNGQAGVQPALGVGL
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| Component 2 |
| Name: | Adenosine receptor A2a |
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| Synonyms: | A2A adenosine receptor (hA2A) | AA2AR_HUMAN | ADENOSINE A2 | ADENOSINE A2a | ADORA2 | ADORA2A | Adenosine A2A receptor (A2AAR) |
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| Type: | G Protein-Coupled Receptor (GPCR) |
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| Mol. Mass.: | 44716.46 |
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| Organism: | Homo sapiens (Human) |
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| Description: | P29274 |
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| Residue: | 412 |
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| Sequence: | MPIMGSSVYITVELAIAVLAILGNVLVCWAVWLNSNLQNVTNYFVVSLAAADIAVGVLAI
PFAITISTGFCAACHGCLFIACFVLVLTQSSIFSLLAIAIDRYIAIRIPLRYNGLVTGTR
AKGIIAICWVLSFAIGLTPMLGWNNCGQPKEGKNHSQGCGEGQVACLFEDVVPMNYMVYF
NFFACVLVPLLLMLGVYLRIFLAARRQLKQMESQPLPGERARSTLQKEVHAAKSLAIIVG
LFALCWLPLHIINCFTFFCPDCSHAPLWLMYLAIVLSHTNSVVNPFIYAYRIREFRQTFR
KIIRSHVLRQQEPFKAAGTSARVLAAHGSDGEQVSLRLNGHPPGVWANGSAPHPERRPNG
YALGLVSGGSAQESQGNTGLPDVELLSHELKGVCPEPPGLDDPLAQDGAGVS
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| BDBM50021087 |
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| n/a |
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| Name | BDBM50021087 |
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| Synonyms: | 2-[4-(1,3-Dimethyl-2,6-dioxo-2,3,6,7-tetrahydro-1H-purin-8-yl)-phenoxy]-N-p-tolyl-acetamide | 2-[4-(1,3-Dimethyl-2,6-dioxo-2,3,6,9-tetrahydro-1H-purin-8-yl)-phenoxy]-N-p-tolyl-acetamide | CHEMBL441598 |
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| Type | Small organic molecule |
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| Emp. Form. | C22H21N5O4 |
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| Mol. Mass. | 419.4332 |
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| SMILES | Cc1ccc(NC(=O)COc2ccc(cc2)-c2nc3n(C)c(=O)n(C)c(=O)c3[nH]2)cc1 |
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| Structure | 
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