| Reaction Details |
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 | Report a problem with these data |
| Target | Potassium voltage-gated channel subfamily A member 6 |
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| Ligand | BDBM50456982 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_1758564 (CHEMBL4193572) |
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| IC50 | 29000±n/a nM |
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| Citation |  Zidar, N; ?ula, A; Toma?i?, T; Rogers, M; Kirby, RW; Tytgat, J; Peigneur, S; Kikelj, D; Ila?, J; Ma?i?, LP Clathrodin, hymenidin and oroidin, and their synthetic analogues as inhibitors of the voltage-gated potassium channels. Eur J Med Chem139:232-241 (2017) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Potassium voltage-gated channel subfamily A member 6 |
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| Name: | Potassium voltage-gated channel subfamily A member 6 |
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| Synonyms: | KCNA6 | KCNA6_HUMAN | Voltage-gated potassium channel | Voltage-gated potassium channel subunit Kv1.6 |
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| Type: | PROTEIN |
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| Mol. Mass.: | 58711.92 |
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| Organism: | Homo sapiens (Human) |
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| Description: | ChEMBL_92811 |
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| Residue: | 529 |
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| Sequence: | MRSEKSLTLAAPGEVRGPEGEQQDAGDFPEAGGGGGCCSSERLVINISGLRFETQLRTLS
LFPDTLLGDPGRRVRFFDPLRNEYFFDRNRPSFDAILYYYQSGGRLRRPVNVPLDIFLEE
IRFYQLGDEALAAFREDEGCLPEGGEDEKPLPSQPFQRQVWLLFEYPESSGPARGIAIVS
VLVILISIVIFCLETLPQFRVDGRGGNNGGVSRVSPVSRGSQEEEEDEDDSYTFHHGITP
GEMGTGGSSSLSTLGGSFFTDPFFLVETLCIVWFTFELLVRFSACPSKPAFFRNIMNIID
LVAIFPYFITLGTELVQQQEQQPASGGGGQNGQQAMSLAILRVIRLVRVFRIFKLSRHSK
GLQILGKTLQASMRELGLLIFFLFIGVILFSSAVYFAEADDDDSLFPSIPDAFWWAVVTM
TTVGYGDMYPMTVGGKIVGSLCAIAGVLTIALPVPVIVSNFNYFYHRETEQEEQGQYTHV
TCGQPAPDLRATDNGLGKPDFPEANRERRPSYLPTPHRAYAEKRMLTEV
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| BDBM50456982 |
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| n/a |
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| Name | BDBM50456982 |
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| Synonyms: | CHEMBL4208517 |
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| Type | Small organic molecule |
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| Emp. Form. | C12H13Br2N5O |
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| Mol. Mass. | 403.073 |
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| SMILES | Cc1[nH]c(C(=O)NC\C=C\c2c[nH]c(N)n2)c(Br)c1Br |
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| Structure | 
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