| Reaction Details |
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 | Report a problem with these data |
| Target | Potassium voltage-gated channel subfamily A member 4 |
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| Ligand | BDBM50456977 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_1758562 (CHEMBL4193570) |
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| IC50 | 13000±n/a nM |
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| Citation |  Zidar, N; ?ula, A; Toma?i?, T; Rogers, M; Kirby, RW; Tytgat, J; Peigneur, S; Kikelj, D; Ila?, J; Ma?i?, LP Clathrodin, hymenidin and oroidin, and their synthetic analogues as inhibitors of the voltage-gated potassium channels. Eur J Med Chem139:232-241 (2017) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Potassium voltage-gated channel subfamily A member 4 |
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| Name: | Potassium voltage-gated channel subfamily A member 4 |
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| Synonyms: | KCNA4 | KCNA4L | KCNA4_HUMAN | Voltage-gated potassium channel | Voltage-gated potassium channel subunit Kv1.4 |
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| Type: | PROTEIN |
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| Mol. Mass.: | 73234.81 |
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| Organism: | Homo sapiens (Human) |
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| Description: | ChEMBL_471773 |
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| Residue: | 653 |
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| Sequence: | MEVAMVSAESSGCNSHMPYGYAAQARARERERLAHSRAAAAAAVAAATAAVEGSGGSGGG
SHHHHQSRGACTSHDPQSSRGSRRRRRQRSEKKKAHYRQSSFPHCSDLMPSGSEEKILRE
LSEEEEDEEEEEEEEEEGRFYYSEDDHGDECSYTDLLPQDEGGGGYSSVRYSDCCERVVI
NVSGLRFETQMKTLAQFPETLLGDPEKRTQYFDPLRNEYFFDRNRPSFDAILYYYQSGGR
LKRPVNVPFDIFTEEVKFYQLGEEALLKFREDEGFVREEEDRALPENEFKKQIWLLFEYP
ESSSPARGIAIVSVLVILISIVIFCLETLPEFRDDRDLVMALSAGGHGGLLNDTSAPHLE
NSGHTIFNDPFFIVETVCIVWFSFEFVVRCFACPSQALFFKNIMNIIDIVSILPYFITLG
TDLAQQQGGGNGQQQQAMSFAILRIIRLVRVFRIFKLSRHSKGLQILGHTLRASMRELGL
LIFFLFIGVILFSSAVYFAEADEPTTHFQSIPDAFWWAVVTMTTVGYGDMKPITVGGKIV
GSLCAIAGVLTIALPVPVIVSNFNYFYHRETENEEQTQLTQNAVSCPYLPSNLLKKFRSS
TSSSLGDKSEYLEMEEGVKESLCAKEEKCQGKGDDSETDKNNCSNAKAVETDV
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| BDBM50456977 |
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| n/a |
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| Name | BDBM50456977 |
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| Synonyms: | CHEMBL3261430 |
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| Type | Small organic molecule |
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| Emp. Form. | C15H15N5O |
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| Mol. Mass. | 281.3125 |
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| SMILES | Nc1nc(\C=C\CNC(=O)c2cc3ccccc3[nH]2)c[nH]1 |
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| Structure | 
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