| Reaction Details |
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 | Report a problem with these data |
| Target | Potassium voltage-gated channel subfamily A member 4 |
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| Ligand | BDBM50220547 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_1758566 (CHEMBL4193574) |
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| IC50 | 5700±n/a nM |
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| Citation |  Zidar, N; ?ula, A; Toma?i?, T; Rogers, M; Kirby, RW; Tytgat, J; Peigneur, S; Kikelj, D; Ila?, J; Ma?i?, LP Clathrodin, hymenidin and oroidin, and their synthetic analogues as inhibitors of the voltage-gated potassium channels. Eur J Med Chem139:232-241 (2017) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Potassium voltage-gated channel subfamily A member 4 |
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| Name: | Potassium voltage-gated channel subfamily A member 4 |
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| Synonyms: | KCNA4_RAT | Kcna4 | Potassium voltage-gated channel subfamily A member 4 | RCK4 | RHK1 | RK3 | Voltage-gated potassium channel subunit Kv1.4 |
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| Type: | PROTEIN |
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| Mol. Mass.: | 73364.40 |
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| Organism: | Rattus norvegicus |
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| Description: | ChEMBL_101243 |
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| Residue: | 655 |
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| Sequence: | MEVAMVSAESSGCNSHMPYGYAAQARARERERLAHSRAAAAAAVAAATAAVEGTGGSGGG
PHHHHQTRGAYSSHDPQGSRGSREEEATRTEKKKKLHHRQSSFPHCSDLMPSGSEEKILR
ELSEEEEDEEEEEEEEEEGRFYYSEEDHGDGCSYTDLLPQDDGGGGGYSSVRYSDCCERV
VINVSGLRFETQMKTLAQFPETLLGDPEKRTQYFDPLRNEYFFDRNRPSFDAILYYYQSG
GRLKRPVNVPFDIFTEEVKFYQLGEEALLKFREDEGFVREEEDRALPENEFKKQIWLLFE
YPESSSPARGIAIVSVLVILISIVIFCLETLPEFRDDRDLIMALSAGGHSRLLNDTSAPH
LENSGHTIFNDPFFIVETVCIVWFSFEFVVRCFACPSQALFFKNIMNIIDIVSILPYFIT
LGTDLAQQQGGGNGQQQQAMSFAILRIIRLVRVFRIFKLSRHSKGLQILGHTLRASMREL
GLLIFFLFIGVILFSSAVYFAEADEPTTHFQSIPDAFWWAVVTMTTVGYGDMKPITVGGK
IVGSLCAIAGVLTIALPVPVIVSNFNYFYHRETENEEQTQLTQNAVSCPYLPSNLLKKFR
SSTSSSLGDKSEYLEMEEGVKESLCGKEEKCQGKGDDSETDKNNCSNAKAVETDV
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| BDBM50220547 |
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| n/a |
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| Name | BDBM50220547 |
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| Synonyms: | 4,5-Dibromo-1H-pyrrole-2-carboxylic acid [3-(2-amino-1H-imidazol-4-yl)-allyl]-amide | 4,5-Dibromo-1H-pyrrole-2-carboxylic acid [3-(2-amino-3H-imidazol-4-yl)-allyl]-amide | CHEMBL397591 | oroidin | oroidin base |
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| Type | Small organic molecule |
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| Emp. Form. | C11H11Br2N5O |
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| Mol. Mass. | 389.046 |
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| SMILES | Nc1ncc(C=CCNC(=O)c2cc(Br)c(Br)[nH]2)[nH]1 |w:6.6| |
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| Structure | 
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