| Reaction Details |
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 | Report a problem with these data |
| Target | Carbonic anhydrase 2 |
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| Ligand | BDBM50456995 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_1758581 (CHEMBL4193589) |
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| Ki | 18±n/a nM |
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| Citation |  Eldehna, WM; Abo-Ashour, MF; Nocentini, A; Gratteri, P; Eissa, IH; Fares, M; Ismael, OE; Ghabbour, HA; Elaasser, MM; Abdel-Aziz, HA; Supuran, CT Novel 4/3-((4-oxo-5-(2-oxoindolin-3-ylidene)thiazolidin-2-ylidene)amino) benzenesulfonamides: Synthesis, carbonic anhydrase inhibitory activity, anticancer activity and molecular modelling studies. Eur J Med Chem139:250-262 (2017) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Carbonic anhydrase 2 |
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| Name: | Carbonic anhydrase 2 |
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| Synonyms: | CA-II | CA2 | CAC | CAH2_HUMAN | Carbonate dehydratase II | Carbonic anhydrase 2 (CA II) | Carbonic anhydrase 2 (CA-II) | Carbonic anhydrase 2 (Recombinant CA II) | Carbonic anhydrase C | Carbonic anhydrase II (CA II) | Carbonic anhydrase II (CA-II) | Carbonic anhydrase II (CAII) | Carbonic anhydrase II (hCA II) | Carbonic anhydrase isoenzyme II (hCA II) |
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| Type: | Enzyme |
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| Mol. Mass.: | 29250.71 |
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| Organism: | Homo sapiens (Human) |
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| Description: | P00918 |
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| Residue: | 260 |
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| Sequence: | MSHHWGYGKHNGPEHWHKDFPIAKGERQSPVDIDTHTAKYDPSLKPLSVSYDQATSLRIL
NNGHAFNVEFDDSQDKAVLKGGPLDGTYRLIQFHFHWGSLDGQGSEHTVDKKKYAAELHL
VHWNTKYGDFGKAVQQPDGLAVLGIFLKVGSAKPGLQKVVDVLDSIKTKGKSADFTNFDP
RGLLPESLDYWTYPGSLTTPPLLECVTWIVLKEPISVSSEQVLKFRKLNFNGEGEPEELM
VDNWRPAQPLKNRQIKASFK
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| BDBM50456995 |
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| n/a |
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| Name | BDBM50456995 |
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| Synonyms: | CHEMBL4206779 |
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| Type | Small organic molecule |
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| Emp. Form. | C18H13BrN4O4S2 |
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| Mol. Mass. | 493.354 |
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| SMILES | CN1C(=O)\C(=C2/S\C(NC2=O)=N\c2ccc(cc2)S(N)(=O)=O)c2cc(Br)ccc12 |
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| Structure | 
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