Ki Summary

Reaction Details

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Target

Platelet-activating factor receptor

Ligand

BDBM50002831

Substrate/Competitor

n/a

Meas. Tech.

ChEBML_151701

IC50

20±n/a nM

Citation

Biftu, T; Gamble, NF; Doebber, T; Hwang, SB; Shen, TY; Snyder, J; Springer, JP; Stevenson, R Conformation and activity of tetrahydrofuran lignans and analogues as specific platelet activating factor antagonists. J Med Chem29:1917-21 (1986) [PubMed]

More Info.:

Get all data from this article, Assay Method

Platelet-activating factor receptor

Name:

Platelet-activating factor receptor

Synonyms:

PAF-R | PTAFR | PTAFR_CAVPO | Platelet activating factor receptor | Platelet-activating factor receptor

Type:

Protein

Mol. Mass.:

39005.63

Organism:

Cavia porcellus

Description:

n/a

Residue:

342

Sequence:

MELNSSSRVDSEFRYTLFPIVYSIIFVLGIIANGYVLWVFARLYPSKKLNEIKIFMVNLT
VADLLFLITLPLWIVYYSNQGNWFLPKFLCNLAGCLFFINTYCSVAFLGVITYNRFQAVK
YPIKTAQATTRKRGIALSLVIWVAIVAAASYFLVMDSTNVVSNKAGSGNITRCFEHYEKG
SKPVLIIHICIVLGFFIVFLLILFCNLVIIHTLLRQPVKQQRNAEVRRRALWMVCTVLAV
FVICFVPHHMVQLPWTLAELGMWPSSNHQAINDAHQVTLCLLSTNCVLDPVIYCFLTKKF
RKHLSEKLNIMRSSQKCSRVTTDTGTEMAIPINHTPVNPIKN

BDBM50002831

n/a

Name

BDBM50002831

Synonyms:

(2R,5R)-2,5-Bis-(3,4,5-trimethoxy-phenyl)-tetrahydro-furan | (2S,5S)-2,5-Bis-(3,4,5-trimethoxy-phenyl)-tetrahydro-furan | (E)-(1R,2R,3R,5R,12S,13R,16S)-16-Hydroxymethyl-5,9,12,13-tetramethyl-4-oxa-tricyclo[10.3.1.0*3,5*]hexadec-8-en-2-ol | (L 652731)2,5-Bis-(3,4,5-trimethoxy-phenyl)-tetrahydro-furan | 2,5-Bis-(3,4,5-trimethoxy-phenyl)-tetrahydro-furan | 2,5-Bis-(3,4,5-trimethoxy-phenyl)-tetrahydro-furan(L-652,731) | 2,5-Bis-(3,4,5-trimethoxy-phenyl)-tetrahydro-furan(L-652731) | CHEMBL297624 | L-652731

Type

Small organic molecule

Emp. Form.

C22H28O7

Mol. Mass.

404.4535

SMILES

COc1cc(cc(OC)c1OC)[C@@H]1CC[C@H](O1)c1cc(OC)c(OC)c(OC)c1

Structure