| Reaction Details |
|---|
 | Report a problem with these data |
| Target | Folate receptor beta |
|---|
| Ligand | BDBM50027655 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | ChEMBL_1759618 (CHEMBL4194626) |
|---|
| IC50 | 746±n/a nM |
|---|
| Citation |  Ravindra, M; Wallace-Povirk, A; Karim, MA; Wilson, MR; O'Connor, C; White, K; Kushner, J; Polin, L; George, C; Hou, Z; Matherly, LH; Gangjee, A Tumor Targeting with Novel Pyridyl 6-Substituted Pyrrolo[2,3- d]Pyrimidine Antifolates via Cellular Uptake by Folate Receptor ? and the Proton-Coupled Folate Transporter and Inhibition of De Novo Purine Nucleotide Biosynthesis. J Med Chem61:2027-2040 (2018) [PubMed] Article |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| Folate receptor beta |
|---|
| Name: | Folate receptor beta |
|---|
| Synonyms: | FBP | FOLR2 | FOLR2_HUMAN | FR-beta | Folate receptor 2 | Folate receptor beta | Folate receptor, fetal/placental | Placental folate-binding protein |
|---|
| Type: | PROTEIN |
|---|
| Mol. Mass.: | 29286.32 |
|---|
| Organism: | Homo sapiens (Human) |
|---|
| Description: | ChEMBL_20077 |
|---|
| Residue: | 255 |
|---|
| Sequence: | MVWKWMPLLLLLVCVATMCSAQDRTDLLNVCMDAKHHKTKPGPEDKLHDQCSPWKKNACC
TASTSQELHKDTSRLYNFNWDHCGKMEPACKRHFIQDTCLYECSPNLGPWIQQVNQSWRK
ERFLDVPLCKEDCQRWWEDCHTSHTCKSNWHRGWDWTSGVNKCPAGALCRTFESYFPTPA
ALCEGLWSHSYKVSNYSRGSGRCIQMWFDSAQGNPNEEVARFYAAAMHVNAGEMLHGTGG
LLLSLALMLQLWLLG
|
|
|
|---|
| BDBM50027655 |
|---|
| n/a |
|---|
| Name | BDBM50027655 |
|---|
| Synonyms: | CHEBI:5847 | Raltitrexed | Tomudex | US9422297, Raltitrexed | ZD-16 | ZD-1694 |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C21H22N4O6S |
|---|
| Mol. Mass. | 458.488 |
|---|
| SMILES | CN(Cc1ccc2[nH]c(C)nc(=O)c2c1)c1ccc(s1)C(=O)N[C@@H](CCC(O)=O)C(O)=O |r| |
|---|
| Structure | 
|
|---|
Search and Browse
