| Reaction Details |
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 | Report a problem with these data |
| Target | Reduced folate transporter |
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| Ligand | BDBM66082 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_1759619 (CHEMBL4194627) |
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| IC50 | 12±n/a nM |
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| Citation |  Ravindra, M; Wallace-Povirk, A; Karim, MA; Wilson, MR; O'Connor, C; White, K; Kushner, J; Polin, L; George, C; Hou, Z; Matherly, LH; Gangjee, A Tumor Targeting with Novel Pyridyl 6-Substituted Pyrrolo[2,3- d]Pyrimidine Antifolates via Cellular Uptake by Folate Receptor ? and the Proton-Coupled Folate Transporter and Inhibition of De Novo Purine Nucleotide Biosynthesis. J Med Chem61:2027-2040 (2018) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Reduced folate transporter |
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| Name: | Reduced folate transporter |
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| Synonyms: | FLOT1 | FOLT | Folate transporter 1 | IFC-1 | Intestinal folate carrier | Placental folate transporter | RFC | RFC1 | Reduced folate carrier protein | S19A1_HUMAN | SLC19A1 | Solute carrier family 19 member 1 |
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| Type: | PROTEIN |
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| Mol. Mass.: | 64885.16 |
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| Organism: | Homo sapiens (Human) |
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| Description: | ChEMBL_1469594 |
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| Residue: | 591 |
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| Sequence: | MVPSSPAVEKQVPVEPGPDPELRSWRHLVCYLCFYGFMAQIRPGESFITPYLLGPDKNFT
REQVTNEITPVLSYSYLAVLVPVFLLTDYLRYTPVLLLQGLSFVSVWLLLLLGHSVAHMQ
LMELFYSVTMAARIAYSSYIFSLVRPARYQRVAGYSRAAVLLGVFTSSVLGQLLVTVGRV
SFSTLNYISLAFLTFSVVLALFLKRPKRSLFFNRDDRGRCETSASELERMNPGPGGKLGH
ALRVACGDSVLARMLRELGDSLRRPQLRLWSLWWVFNSAGYYLVVYYVHILWNEVDPTTN
SARVYNGAADAASTLLGAITSFAAGFVKIRWARWSKLLIAGVTATQAGLVFLLAHTRHPS
SIWLCYAAFVLFRGSYQFLVPIATFQIASSLSKELCALVFGVNTFFATIVKTIITFIVSD
VRGLGLPVRKQFQLYSVYFLILSIIYFLGAMLDGLRHCQRGHHPRQPPAQGLRSAAEEKA
AQALSVQDKGLGGLQPAQSPPLSPEDSLGAVGPASLEQRQSDPYLAQAPAPQAAEFLSPV
TTPSPCTLCSAQASGPEAADETCPQLAVHPPGVSKLGLQCLPSDGVQNVNQ
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| BDBM66082 |
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| n/a |
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| Name | BDBM66082 |
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| Synonyms: | (2S)-2-[[4-[(2,4-diaminopteridin-6-yl)methyl-methyl-amino]benzoyl]amino]glutaric acid;hydrate | (2S)-2-[[4-[(2,4-diaminopteridin-6-yl)methyl-methylamino]benzoyl]amino]pentanedioic acid;hydrate | (2S)-2-[[4-[[2,4-bis(azanyl)pteridin-6-yl]methyl-methyl-amino]phenyl]carbonylamino]pentanedioic acid;hydrate | (2S)-2-[[[4-[(2,4-diamino-6-pteridinyl)methyl-methylamino]phenyl]-oxomethyl]amino]pentanedioic acid;hydrate | L-Glutamic acid, N-[4-[[(2,4-diamino-6-pteridinyl)methyl]methylamino]benzoyl]- [CAS] | MLS001401431 | SMR000449324 | US11530198, Example Methotrexate | cid_165528 |
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| Type | Small organic molecule |
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| Emp. Form. | C20H22N8O5 |
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| Mol. Mass. | 454.4393 |
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| SMILES | CN(Cc1cnc2nc(N)nc(N)c2n1)c1ccc(cc1)C(=O)N[C@@H](CCC(O)=O)C(O)=O |
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| Structure | 
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