Reaction Details |
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Target | Retinoic acid receptor beta |
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Ligand | BDBM50048291 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEMBL_1760058 (CHEMBL4195066) |
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EC50 | 226±n/a nM |
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Citation | Thoreau, E; Arlabosse, JM; Bouix-Peter, C; Chambon, S; Chantalat, L; Daver, S; Dumais, L; Duvert, G; Feret, A; Ouvry, G; Pascau, J; Raffin, C; Rodeville, N; Soulet, C; Tabet, S; Talano, S; Portal, T Structure-based design of Trifarotene (CD5789), a potent and selective RAR? agonist for the treatment of acne. Bioorg Med Chem Lett28:1736-1741 (2018) [PubMed] Article |
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More Info.: | Get all data from this article, Assay Method |
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Retinoic acid receptor beta |
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Name: | Retinoic acid receptor beta |
Synonyms: | HAP | HBV-activated protein | NR1B2 | Nuclear receptor subfamily 1 group B member 2 | RAR-beta | RAR-epsilon | RARB | RARB_HUMAN | Retinoic acid receptor RXR-alpha/Retinoic acid receptor beta | Retinoic acid receptor beta | Retinoid receptor |
Type: | PROTEIN |
Mol. Mass.: | 50498.70 |
Organism: | Homo sapiens (Human) |
Description: | ChEMBL_1458015 |
Residue: | 455 |
Sequence: | MTTSGHACPVPAVNGHMTHYPATPYPLLFPPVIGGLSLPPLHGLHGHPPPSGCSTPSPAT
IETQSTSSEELVPSPPSPLPPPRVYKPCFVCQDKSSGYHYGVSACEGCKGFFRRSIQKNM
IYTCHRDKNCVINKVTRNRCQYCRLQKCFEVGMSKESVRNDRNKKKKETSKQECTESYEM
TAELDDLTEKIRKAHQETFPSLCQLGKYTTNSSADHRVRLDLGLWDKFSELATKCIIKIV
EFAKRLPGFTGLTIADQITLLKAACLDILILRICTRYTPEQDTMTFSDGLTLNRTQMHNA
GFGPLTDLVFTFANQLLPLEMDDTETGLLSAICLICGDRQDLEEPTKVDKLQEPLLEALK
IYIRKRRPSKPHMFPKILMKITDLRSISAKGAERVITLKMEIPGSMPPLIQEMLENSEGH
EPLTPSSSGNTAEHSPSISPSSVENSGVSQSPLVQ
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BDBM50048291 |
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n/a |
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Name | BDBM50048291 |
Synonyms: | 6-(3-Adamantan-1-yl-4-hydroxy-phenyl)-naphthalene-2-carboxylic acid | 6-[3'-(1-adamantyl)-4'-hydroxyphenyl]-2-naphthalenecarboxylic acid | 6-[3'-(1-adamantyl)-4'-hydroxyphenyl]-2-naphthoic acid | CHEMBL1180 | O-Demethylated Adapalene |
Type | Small organic molecule |
Emp. Form. | C27H26O3 |
Mol. Mass. | 398.4935 |
SMILES | OC(=O)c1ccc2cc(ccc2c1)-c1ccc(O)c(c1)C12CC3CC(CC(C3)C1)C2 |TLB:18:20:23:27.26.25,THB:21:22:25:29.20.28,21:20:23.22.27:25,28:20:23:27.26.25,28:26:23:29.21.20| |
Structure |
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