| Reaction Details |
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 | Report a problem with these data |
| Target | 5-hydroxytryptamine receptor 1A |
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| Ligand | BDBM50457575 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_1760115 (CHEMBL4195123) |
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| Ki | 0.700000±n/a nM |
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| Citation |  Pa?czyk, K; Pytka, K; Jakubczyk, M; Rapacz, A; Sa?at, K; Furga?a, A; Siwek, A; G?uch-Lutwin, M; Grybo?, A; S?oczy?ska, K; P?kala, E; ?mudzki, P; Bucki, A; Ko?aczkowski, M; ?elaszczyk, D; Marona, H; Waszkielewicz, AM Synthesis and activity of di- or trisubstituted N-(phenoxyalkyl)- or N-{2-[2-(phenoxy)ethoxy]ethyl}piperazine derivatives on the central nervous system. Bioorg Med Chem Lett28:2039-2049 (2018) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| 5-hydroxytryptamine receptor 1A |
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| Name: | 5-hydroxytryptamine receptor 1A |
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| Synonyms: | 5-HT-1A | 5-HT1 | 5-HT1A | 5-Hydroxytryptamine receptor 1A (5-HT1A) | 5-hydroxytryptamine receptor 1A (5HT1A) | 5HT1A_RAT | 5ht1a | G-21 | Htr1a | Serotonin 1 (5-HT1) receptor | Serotonin 1a (5-HT1a) receptor/Adrenergic receptor alpha-1 | Serotonin receptor 1A |
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| Type: | G Protein-Coupled Receptor (GPCR) |
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| Mol. Mass.: | 46445.29 |
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| Organism: | Rattus norvegicus (rat) |
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| Description: | Binding assays were performed using rat hippocampal membranes. |
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| Residue: | 422 |
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| Sequence: | MDVFSFGQGNNTTASQEPFGTGGNVTSISDVTFSYQVITSLLLGTLIFCAVLGNACVVAA
IALERSLQNVANYLIGSLAVTDLMVSVLVLPMAALYQVLNKWTLGQVTCDLFIALDVLCC
TSSILHLCAIALDRYWAITDPIDYVNKRTPRRAAALISLTWLIGFLISIPPMLGWRTPED
RSDPDACTISKDHGYTIYSTFGAFYIPLLLMLVLYGRIFRAARFRIRKTVRKVEKKGAGT
SLGTSSAPPPKKSLNGQPGSGDWRRCAENRAVGTPCTNGAVRQGDDEATLEVIEVHRVGN
SKEHLPLPSESGSNSYAPACLERKNERNAEAKRKMALARERKTVKTLGIIMGTFILCWLP
FFIVALVLPFCESSCHMPALLGAIINWLGYSNSLLNPVIYAYFNKDFQNAFKKIIKCKFC
RR
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| BDBM50457575 |
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| n/a |
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| Name | BDBM50457575 |
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| Synonyms: | CHEMBL3979261 |
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| Type | Small organic molecule |
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| Emp. Form. | C22H31ClN2O2 |
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| Mol. Mass. | 390.947 |
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| SMILES | Cl.COc1ccccc1N1CCN(CCCOc2c(C)cccc2C)CC1 |
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| Structure | 
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