Ki Summary

Reaction Details

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Target

Thymidine kinase, cytosolic

Ligand

BDBM50021777

Substrate/Competitor

n/a

Meas. Tech.

ChEBML_207850

25000±n/a nM

Citation

Haines, DR; Tseng, CK; Marquez, VE Synthesis and biological activity of unsaturated carboacyclic purine nucleoside analogues. J Med Chem30:943-7 (1987) [PubMed]

More Info.:

Get all data from this article, Assay Method

Thymidine kinase, cytosolic

Name:

Thymidine kinase, cytosolic

Synonyms:

KITH_HUMAN | TK1

Type:

PROTEIN

Mol. Mass.:

25476.50

Organism:

Homo sapiens (Human)

Description:

ChEMBL_1333884

Residue:

234

Sequence:

MSCINLPTVLPGSPSKTRGQIQVILGPMFSGKSTELMRRVRRFQIAQYKCLVIKYAKDTR
YSSSFCTHDRNTMEALPACLLRDVAQEALGVAVIGIDEGQFFPDIVEFCEAMANAGKTVI
VAALDGTFQRKPFGAILNLVPLAESVVKLTAVCMECFREAAYTKRLGTEKEVEVIGGADK
YHSVCRLCYFKKASGQPAGPDNKENCPVPGKPGEAVAARKLFAPQQILQCSPAN

BDBM50021777

n/a

Name

BDBM50021777

Synonyms:

2-Amino-9-(4-hydroxy-3-hydroxymethyl-but-2-enyl)-1,9-dihydro-purin-6-one | CHEMBL306477

Type

Small organic molecule

Emp. Form.

C10H13N5O3

Mol. Mass.

251.2419

SMILES

Nc1nc2n(CC=C(CO)CO)cnc2c(=O)[nH]1 |(-1.17,-10.79,;.17,-10.04,;1.48,-10.8,;2.83,-10.04,;4.29,-10.48,;4.78,-11.96,;6.51,-11.96,;7.73,-13.11,;9.14,-12.79,;9.3,-11.38,;7.83,-14.78,;6.74,-15.85,;5.2,-9.23,;4.27,-8.01,;2.82,-8.5,;1.48,-7.73,;1.48,-6.19,;.17,-8.5,)|

Structure