| Reaction Details |
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 | Report a problem with these data |
| Target | Ditrans,polycis-undecaprenyl-diphosphate synthase ((2E,6E)-farnesyl-diphosphate specific) |
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| Ligand | BDBM50458053 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_1761930 (CHEMBL4197177) |
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| IC50 | 38000±n/a nM |
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| Citation |  Elsebaei, MM; Mohammad, H; Abouf, M; Abutaleb, NS; Hegazy, YA; Ghiaty, A; Chen, L; Zhang, J; Malwal, SR; Oldfield, E; Seleem, MN; Mayhoub, AS Alkynyl-containing phenylthiazoles: Systemically active antibacterial agents effective against methicillin-resistant Staphylococcus aureus (MRSA). Eur J Med Chem148:195-209 (2018) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Ditrans,polycis-undecaprenyl-diphosphate synthase ((2E,6E)-farnesyl-diphosphate specific) |
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| Name: | Ditrans,polycis-undecaprenyl-diphosphate synthase ((2E,6E)-farnesyl-diphosphate specific) |
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| Synonyms: | 2.5.1.31 | Ditrans,polycis-undecaprenylcistransferase | UDS | UPP synthase | UPPS_ECOLI | Undecaprenyl diphosphate synthase | Undecaprenyl pyrophosphate synthase | ispU | rth | uppS | yaeS |
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| Type: | PROTEIN |
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| Mol. Mass.: | 28445.82 |
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| Organism: | Escherichia coli (strain K12) |
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| Description: | ChEMBL_117825 |
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| Residue: | 253 |
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| Sequence: | MMLSATQPLSEKLPAHGCRHVAIIMDGNGRWAKKQGKIRAFGHKAGAKSVRRAVSFAANN
GIEALTLYAFSSENWNRPAQEVSALMELFVWALDSEVKSLHRHNVRLRIIGDTSRFNSRL
QERIRKSEALTAGNTGLTLNIAANYGGRWDIVQGVRQLAEKVQQGNLQPDQIDEEMLNQH
VCMHELAPVDLVIRTGGEHRISNFLLWQIAYAELYFTDVLWPDFDEQDFEGALNAFANRE
RRFGGTEPGDETA
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| BDBM50458053 |
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| n/a |
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| Name | BDBM50458053 |
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| Synonyms: | CHEMBL4214440 |
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| Type | Small organic molecule |
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| Emp. Form. | C18H19N5S |
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| Mol. Mass. | 337.442 |
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| SMILES | C\C(=N/NC(N)=N)c1sc(nc1C)-c1ccc(cc1)C#CC1CC1 |
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| Structure | 
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