| Reaction Details |
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 | Report a problem with these data |
| Target | Aldo-keto reductase family 1 member B1 |
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| Ligand | BDBM50022260 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEBML_31911 |
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| IC50 | 770±n/a nM |
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| Citation |  Cerelli, MJ; Curtis, DL; Dunn, JP; Nelson, PH; Peak, TM; Waterbury, LD Antiinflammatory and aldose reductase inhibitory activity of some tricyclic arylacetic acids. J Med Chem29:2347-51 (1986) [PubMed] |
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| More Info.: | Get all data from this article, Assay Method |
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| Aldo-keto reductase family 1 member B1 |
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| Name: | Aldo-keto reductase family 1 member B1 |
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| Synonyms: | AKR1B1 | ALDR1 | ALDR_HUMAN | ALR2 | AR | Aldo-keto reductase family 1 member B1 (AKR1B1) | Aldose Reductase (ALR2) | Aldose reductase | Aldose reductase (AR) |
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| Type: | Protein |
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| Mol. Mass.: | 35855.50 |
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| Organism: | Homo sapiens (Human) |
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| Description: | P15121. 4LAU; 2IKI; 4LB4; 2FZD; 2FZ8; 1US0 |
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| Residue: | 316 |
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| Sequence: | MASRLLLNNGAKMPILGLGTWKSPPGQVTEAVKVAIDVGYRHIDCAHVYQNENEVGVAIQ
EKLREQVVKREELFIVSKLWCTYHEKGLVKGACQKTLSDLKLDYLDLYLIHWPTGFKPGK
EFFPLDESGNVVPSDTNILDTWAAMEELVDEGLVKAIGISNFNHLQVEMILNKPGLKYKP
AVNQIECHPYLTQEKLIQYCQSKGIVVTAYSPLGSPDRPWAKPEDPSLLEDPRIKAIAAK
HNKTTAQVLIRFPMQRNLVVIPKSVTPERIAENFKVFDFELSSQDMTTLLSYNRNWRVCA
LLSCTSHKDYPFHEEF
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| BDBM50022260 |
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| n/a |
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| Name | BDBM50022260 |
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| Synonyms: | 11,12-Dihydro-3H-1-oxa-benzo[4,5]cyclohepta[1,2-e]indene-2,6-dione | CHEMBL311679 |
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| Type | Small organic molecule |
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| Emp. Form. | C17H12O3 |
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| Mol. Mass. | 264.2754 |
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| SMILES | O=C1Cc2ccc3c(CCc4ccccc4C3=O)c2O1 |
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| Structure | 
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