Ki Summary

Reaction Details

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Target

5-hydroxytryptamine receptor 7

Ligand

BDBM50098550

Substrate/Competitor

n/a

Meas. Tech.

ChEMBL_1764020 (CHEMBL4199267)

32±n/a nM

Citation

Modica, MN; Lacivita, E; Intagliata, S; Salerno, L; Romeo, G; Pittal�, V; Leopoldo, M Structure-Activity Relationships and Therapeutic Potentials of 5-HT J Med Chem61:8475-8503 (2018) [PubMed] Article

More Info.:

Get all data from this article, Assay Method

5-hydroxytryptamine receptor 7

Name:

5-hydroxytryptamine receptor 7

Synonyms:

5-HT-7 | 5-HT-X | 5-HT7 | 5-HT7L | 5-HT7S | 5-HT7b | 5HT7 | 5HT7R_HUMAN | HTR7 | Serotonin receptor 7

Type:

G Protein-Coupled Receptor (GPCR)

Mol. Mass.:

53573.08

Organism:

Homo sapiens (Human)

Description:

P34969

Residue:

479

Sequence:

MMDVNSSGRPDLYGHLRSFLLPEVGRGLPDLSPDGGADPVAGSWAPHLLSEVTASPAPTW
DAPPDNASGCGEQINYGRVEKVVIGSILTLITLLTIAGNCLVVISVCFVKKLRQPSNYLI
VSLALADLSVAVAVMPFVSVTDLIGGKWIFGHFFCNVFIAMDVMCCTASIMTLCVISIDR
YLGITRPLTYPVRQNGKCMAKMILSVWLLSASITLPPLFGWAQNVNDDKVCLISQDFGYT
IYSTAVAFYIPMSVMLFMYYQIYKAARKSAAKHKFPGFPRVEPDSVIALNGIVKLQKEVE
ECANLSRLLKHERKNISIFKREQKAATTLGIIVGAFTVCWLPFFLLSTARPFICGTSCSC
IPLWVERTFLWLGYANSLINPFIYAFFNRDLRTTYRSLLQCQYRNINRKLSAAGMHEALK
LAERPERPEFVLRACTRRVLLRPEKRPPVSVWVLQSPDHHNWLADKMLTTVEKKVMIHD

BDBM50098550

n/a

Name

BDBM50098550

Synonyms:

3,N-Dimethyl-N-[(R)-1-methyl-3-(4-methyl-piperidin-1-yl)-propyl]-benzenesulfonamide | 3,N-Dimethyl-N-[1-methyl-3-(4-methyl-piperidin-1-yl)-propyl]-benzenesulfonamide | 3,N-Dimethyl-N-[1-methyl-3-(4-methyl-piperidin-1-yl)-propyl]-benzenesulfonamide (SB-258719) | 4-Methyl-1-[(R)-3-methyl-4-(toluene-3-sulfonyl)-pentyl]-piperidine | CHEMBL12264 | SB-258719

Type

Small organic molecule

Emp. Form.

C18H30N2O2S

Mol. Mass.

338.508

SMILES

C[C@H](CCN1CCC(C)CC1)N(C)S(=O)(=O)c1cccc(C)c1

Structure