Reaction Details | |||
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Target | Tyrosine-protein kinase Tec | ||
Ligand | BDBM50458589 | ||
Substrate/Competitor | n/a | ||
Meas. Tech. | ChEMBL_1764259 (CHEMBL4199506) | ||
IC50 | 0.740000±n/a nM | ||
Citation | Blass, BE Covalent Inhibitors of the TEC Family of Kinases and Their Methods of Use. ACS Med Chem Lett9:587-589 (2018) [PubMed] Article | ||
More Info.: | Get all data from this article, Assay Method | ||
Tyrosine-protein kinase Tec | |||
Name: | Tyrosine-protein kinase Tec | ||
Synonyms: | PSCTK4 | TEC | TEC_HUMAN | Tyrosine-protein kinase TEC (TEC) | ||
Type: | Protein | ||
Mol. Mass.: | 73597.00 | ||
Organism: | Homo sapiens (Human) | ||
Description: | n/a | ||
Residue: | 631 | ||
Sequence: |
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BDBM50458589 | |||
n/a | |||
Name | BDBM50458589 | ||
Synonyms: | CHEMBL4208358 | US10752615, Compound 57 | ||
Type | Small organic molecule | ||
Emp. Form. | C25H22FN5O3S | ||
Mol. Mass. | 491.537 | ||
SMILES | Fc1ccc2n([C@H]3C[C@]4(C3)CCN(C4)C(=O)C=C)c(NC(=O)c3ccc(s3)-c3cnco3)nc2c1 |r,wU:8.10,6.5,(6.64,-6.08,;7.97,-6.84,;7.97,-8.39,;9.3,-9.16,;10.64,-8.39,;12.12,-8.86,;12.6,-10.32,;13.98,-11.01,;13.28,-12.39,;11.91,-11.7,;14.79,-12.72,;14.94,-14.25,;13.53,-14.87,;12.5,-13.72,;13.2,-16.38,;14.34,-17.41,;11.73,-16.84,;11.4,-18.35,;13.03,-7.6,;14.57,-7.59,;15.33,-6.25,;14.55,-4.92,;16.86,-6.24,;17.75,-4.98,;19.21,-5.45,;19.23,-6.98,;17.77,-7.47,;20.47,-7.87,;21.93,-7.39,;22.84,-8.62,;21.95,-9.87,;20.49,-9.4,;12.11,-6.35,;10.63,-6.84,;9.3,-6.07,)| | ||
Structure |