| Reaction Details |
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 | Report a problem with these data |
| Target | Renin |
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| Ligand | BDBM50022610 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEBML_195784 |
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| IC50 | 1.5±n/a nM |
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| Citation |  Luly, JR; BaMaung, N; Soderquist, J; Fung, AK; Stein, H; Kleinert, HD; Marcotte, PA; Egan, DA; Bopp, B; Merits, I Renin inhibitors. Dipeptide analogues of angiotensinogen utilizing a dihydroxyethylene transition-state mimic at the scissile bond to impart greater inhibitory potency. J Med Chem31:2264-76 (1989) [PubMed] |
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| More Info.: | Get all data from this article, Assay Method |
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| Renin |
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| Name: | Renin |
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| Synonyms: | Angiotensinogenase | REN | RENI_HUMAN |
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| Type: | Enzyme |
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| Mol. Mass.: | 45058.99 |
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| Organism: | Homo sapiens (Human) |
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| Description: | n/a |
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| Residue: | 406 |
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| Sequence: | MDGWRRMPRWGLLLLLWGSCTFGLPTDTTTFKRIFLKRMPSIRESLKERGVDMARLGPEW
SQPMKRLTLGNTTSSVILTNYMDTQYYGEIGIGTPPQTFKVVFDTGSSNVWVPSSKCSRL
YTACVYHKLFDASDSSSYKHNGTELTLRYSTGTVSGFLSQDIITVGGITVTQMFGEVTEM
PALPFMLAEFDGVVGMGFIEQAIGRVTPIFDNIISQGVLKEDVFSFYYNRDSENSQSLGG
QIVLGGSDPQHYEGNFHYINLIKTGVWQIQMKGVSVGSSTLLCEDGCLALVDTGASYISG
STSSIEKLMEALGAKKRLFDYVVKCNEGPTLPDISFHLGGKEYTLTSADYVFQESYSSKK
LCTLAIHAMDIPPPTGPTWALGATFIRKFYTEFDRRNNRIGFALAR
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| BDBM50022610 |
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| n/a |
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| Name | BDBM50022610 |
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| Synonyms: | CHEMBL3348557 | {1-[1-(1-Cyclohexylmethyl-2,3-dihydroxy-4-methyl-pentylcarbamoyl)-2-(4H-imidazol-4-yl)-ethylcarbamoyl]-2-phenyl-ethyl}-carbamic acid tert-butyl ester |
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| Type | Small organic molecule |
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| Emp. Form. | C33H51N5O6 |
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| Mol. Mass. | 613.7879 |
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| SMILES | CC(C)[C@H](O)[C@H](O)[C@H](CC1CCCCC1)NC(=O)[C@H](Cc1c[nH]cn1)NC(=O)[C@H](Cc1ccccc1)NC(=O)OC(C)(C)C |
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| Structure | 
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