| Reaction Details |
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 | Report a problem with these data |
| Target | Transthyretin |
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| Ligand | BDBM50108877 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_1765443 (CHEMBL4200690) |
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| Kd | 21±n/a nM |
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| Citation |  Miller, M; Pal, A; Albusairi, W; Joo, H; Pappas, B; Haque Tuhin, MT; Liang, D; Jampala, R; Liu, F; Khan, J; Faaij, M; Park, M; Chan, W; Graef, I; Zamboni, R; Kumar, N; Fox, J; Sinha, U; Alhamadsheh, M Enthalpy-Driven Stabilization of Transthyretin by AG10 Mimics a Naturally Occurring Genetic Variant That Protects from Transthyretin Amyloidosis. J Med Chem61:7862-7876 (2018) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Transthyretin |
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| Name: | Transthyretin |
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| Synonyms: | ATTR | PALB | Prealbumin | TBPA | TTHY_HUMAN | TTR | Transthyretin (TTR) |
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| Type: | Enzyme |
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| Mol. Mass.: | 15884.31 |
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| Organism: | Homo sapiens (Human) |
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| Description: | P02766 |
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| Residue: | 147 |
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| Sequence: | MASHRLLLLCLAGLVFVSEAGPTGTGESKCPLMVKVLDAVRGSPAINVAVHVFRKAADDT
WEPFASGKTSESGELHGLTTEEEFVEGIYKVEIDTKSYWKALGISPFHEHAEVVFTANDS
GPRRYTIAALLSPYSYSTTAVVTNPKE
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| BDBM50108877 |
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| n/a |
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| Name | BDBM50108877 |
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| Synonyms: | (3,4-Dihydroxy-5-nitro-phenyl)-p-tolyl-methanone | (3,4-dihydroxy-5-nitrophenyl)(p-tolyl)methanone | CHEMBL1324 | Ro-40-7592 | TOLCAPONE | Talcapone | Tasmar |
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| Type | Small organic molecule |
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| Emp. Form. | C14H11NO5 |
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| Mol. Mass. | 273.2408 |
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| SMILES | Cc1ccc(cc1)C(=O)c1cc(O)c(O)c(c1)[N+]([O-])=O |
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| Structure | 
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