Reaction Details |
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Target | Cytochrome P450 3A4 |
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Ligand | BDBM50459192 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEMBL_1765748 (CHEMBL4200995) |
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IC50 | 50±n/a nM |
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Citation | Bardiot, D; Koukni, M; Smets, W; Carlens, G; McNaughton, M; Kaptein, S; Dallmeier, K; Chaltin, P; Neyts, J; Marchand, A Discovery of Indole Derivatives as Novel and Potent Dengue Virus Inhibitors. J Med Chem61:8390-8401 (2018) [PubMed] Article |
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More Info.: | Get all data from this article, Assay Method |
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Cytochrome P450 3A4 |
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Name: | Cytochrome P450 3A4 |
Synonyms: | Albendazole monooxygenase | Albendazole sulfoxidase | CP3A4_HUMAN | CYP3A3 | CYP3A4 | CYPIIIA3 | CYPIIIA4 | Cytochrome P450 3A3 | Cytochrome P450 3A4 (CYP3A4) | Cytochrome P450 HLp | Nifedipine oxidase | Quinine 3-monooxygenase | Taurochenodeoxycholate 6-alpha-hydroxylase |
Type: | Enzyme |
Mol. Mass.: | 57349.57 |
Organism: | Homo sapiens (Human) |
Description: | n/a |
Residue: | 503 |
Sequence: | MALIPDLAMETWLLLAVSLVLLYLYGTHSHGLFKKLGIPGPTPLPFLGNILSYHKGFCMF
DMECHKKYGKVWGFYDGQQPVLAITDPDMIKTVLVKECYSVFTNRRPFGPVGFMKSAISI
AEDEEWKRLRSLLSPTFTSGKLKEMVPIIAQYGDVLVRNLRREAETGKPVTLKDVFGAYS
MDVITSTSFGVNIDSLNNPQDPFVENTKKLLRFDFLDPFFLSITVFPFLIPILEVLNICV
FPREVTNFLRKSVKRMKESRLEDTQKHRVDFLQLMIDSQNSKETESHKALSDLELVAQSI
IFIFAGYETTSSVLSFIMYELATHPDVQQKLQEEIDAVLPNKAPPTYDTVLQMEYLDMVV
NETLRLFPIAMRLERVCKKDVEINGMFIPKGVVVMIPSYALHRDPKYWTEPEKFLPERFS
KKNKDNIDPYIYTPFGSGPRNCIGMRFALMNMKLALIRVLQNFSFKPCKETQIPLKLSLG
GLLQPEKPVVLKVESRDGTVSGA
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BDBM50459192 |
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n/a |
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Name | BDBM50459192 |
Synonyms: | CHEMBL4205724 |
Type | Small organic molecule |
Emp. Form. | C22H19N3O2 |
Mol. Mass. | 357.4052 |
SMILES | COc1cncc(NC(C(=O)c2c[nH]c3ccccc23)c2ccccc2)c1 |
Structure |
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