| Reaction Details |
|---|
 | Report a problem with these data |
| Target | Urotensin-2 receptor |
|---|
| Ligand | BDBM50445383 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | ChEMBL_1766069 (CHEMBL4201316) |
|---|
| EC50 | 3.6±n/a nM |
|---|
| Citation |  Billard, E; Hébert, TE; Chatenet, D Discovery of New Allosteric Modulators of the Urotensinergic System through Substitution of the Urotensin II-Related Peptide (URP) Phenylalanine Residue. J Med Chem61:8707-8716 (2018) [PubMed] Article |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| Urotensin-2 receptor |
|---|
| Name: | Urotensin-2 receptor |
|---|
| Synonyms: | G-protein coupled receptor 14 | GPR14 | UR-II-R | UR2R_HUMAN | UTS2R | Urotensin II receptor | Urotensin-II |
|---|
| Type: | Enzyme Catalytic Domain |
|---|
| Mol. Mass.: | 42159.71 |
|---|
| Organism: | Homo sapiens (Human) |
|---|
| Description: | Urotensin-II UTS2R HUMAN::Q9UKP6 |
|---|
| Residue: | 389 |
|---|
| Sequence: | MALTPESPSSFPGLAATGSSVPEPPGGPNATLNSSWASPTEPSSLEDLVATGTIGTLLSA
MGVVGVVGNAYTLVVTCRSLRAVASMYVYVVNLALADLLYLLSIPFIVATYVTKEWHFGD
VGCRVLFGLDFLTMHASIFTLTVMSSERYAAVLRPLDTVQRPKGYRKLLALGTWLLALLL
TLPVMLAMRLVRRGPKSLCLPAWGPRAHRAYLTLLFATSIAGPGLLIGLLYARLARAYRR
SQRASFKRARRPGARALRLVLGIVLLFWACFLPFWLWQLLAQYHQAPLAPRTARIVNYLT
TCLTYGNSCANPFLYTLLTRNYRDHLRGRVRGPGSGGGRGPVPSLQPRARFQRCSGRSLS
SCSPQPTDSLVLAPAAPARPAPEGPRAPA
|
|
|
|---|
| BDBM50445383 |
|---|
| n/a |
|---|
| Name | BDBM50445383 |
|---|
| Synonyms: | CHEMBL3104471 |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C49H64N10O10S2 |
|---|
| Mol. Mass. | 1017.223 |
|---|
| SMILES | CC(C)[C@H](NC(=O)[C@@H]1CSSC[C@H](NC(=O)[C@H](C)N)C(=O)N[C@@H](Cc2ccccc2)C(=O)N[C@@H](Cc2c[nH]c3ccccc23)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](Cc2ccc(O)cc2)C(=O)N1)C(O)=O |r| |
|---|
| Structure | 
|
|---|
Search and Browse
