| Reaction Details |
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 | Report a problem with these data |
| Target | G-protein coupled estrogen receptor 1 |
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| Ligand | BDBM50459750 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_1767035 (CHEMBL4202282) |
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| EC50 | 480±n/a nM |
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| Citation |  O'Dea, A; Sondergard, C; Sweeney, P; Arnatt, CK A Series of Indole-Thiazole Derivatives Act as GPER Agonists and Inhibit Breast Cancer Cell Growth. ACS Med Chem Lett9:901-906 (2018) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| G-protein coupled estrogen receptor 1 |
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| Name: | G-protein coupled estrogen receptor 1 |
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| Synonyms: | CEPR | CMKRL2 | DRY12 | G-protein coupled estrogen receptor 1 | G-protein-coupled receptor (GPR30 ) | GPER | GPER1 | GPER1_HUMAN | GPR30 |
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| Type: | PROTEIN |
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| Mol. Mass.: | 42259.21 |
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| Organism: | Homo sapiens (Human) |
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| Description: | ChEMBL_982507 |
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| Residue: | 375 |
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| Sequence: | MDVTSQARGVGLEMYPGTAQPAAPNTTSPELNLSHPLLGTALANGTGELSEHQQYVIGLF
LSCLYTIFLFPIGFVGNILILVVNISFREKMTIPDLYFINLAVADLILVADSLIEVFNLH
ERYYDIAVLCTFMSLFLQVNMYSSVFFLTWMSFDRYIALARAMRCSLFRTKHHARLSCGL
IWMASVSATLVPFTAVHLQHTDEACFCFADVREVQWLEVTLGFIVPFAIIGLCYSLIVRV
LVRAHRHRGLRPRRQKALRMILAVVLVFFVCWLPENVFISVHLLQRTQPGAAPCKQSFRH
AHPLTGHIVNLAAFSNSCLNPLIYSFLGETFRDKLRLYIEQKTNLPALNRFCHAALKAVI
PDSTEQSDVRFSSAV
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| BDBM50459750 |
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| n/a |
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| Name | BDBM50459750 |
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| Synonyms: | CHEMBL4204670 |
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| Type | Small organic molecule |
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| Emp. Form. | C15H13BrClN3OS |
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| Mol. Mass. | 398.705 |
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| SMILES | CCc1nc(NC(=O)c2[nH]c3ccc(Br)cc3c2Cl)sc1C |
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| Structure | 
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