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| Reaction Details | |||
|---|---|---|---|
 | Report a problem with these data | ||
| Target | Bromodomain-containing protein 2 | ||
| Ligand | BDBM50459819 | ||
| Substrate/Competitor | n/a | ||
| Meas. Tech. | ChEMBL_1767164 (CHEMBL4219276) | ||
| Ki | 0.900000±n/a nM | ||
| Citation |  Zhou, B; Hu, J; Xu, F; Chen, Z; Bai, L; Fernandez-Salas, E; Lin, M; Liu, L; Yang, CY; Zhao, Y; McEachern, D; Przybranowski, S; Wen, B; Sun, D; Wang, S Discovery of a Small-Molecule Degrader of Bromodomain and Extra-Terminal (BET) Proteins with Picomolar Cellular Potencies and Capable of Achieving Tumor Regression. J Med Chem61:462-481 (2018) [PubMed] Article | ||
| More Info.: | Get all data from this article, Assay Method | ||
| Bromodomain-containing protein 2 | |||
| Name: | Bromodomain-containing protein 2 | ||
| Synonyms: | BRD2 | BRD2_HUMAN | Bromodomain and extra-terminal motif (BET) | Bromodomain-containing protein 2 | Bromodomain-containing protein 2 (BRD2) | KIAA9001 | RING3 | ||
| Type: | Protein | ||
| Mol. Mass.: | 88085.95 | ||
| Organism: | Homo sapiens (Human) | ||
| Description: | P25440 | ||
| Residue: | 801 | ||
| Sequence: |
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| BDBM50459819 | |||
| n/a | |||
| Name | BDBM50459819 | ||
| Synonyms: | CHEMBL4228445 | ||
| Type | Small organic molecule | ||
| Emp. Form. | C26H28N8O3 | ||
| Mol. Mass. | 500.5523 | ||
| SMILES | CCn1nc(cc1Nc1nc(nc2[nH]c3cc(-c4c(C)noc4C)c(OC)cc3c12)C(=O)NC)C1CC1 |(34.96,-28.14,;33.49,-28.62,;32.34,-27.6,;32.49,-26.07,;31.08,-25.45,;30.06,-26.6,;30.85,-27.93,;30.23,-29.34,;31.14,-30.58,;32.66,-30.41,;33.58,-31.65,;32.96,-33.05,;31.44,-33.22,;30.55,-34.48,;29.08,-34.01,;27.74,-34.79,;26.4,-34.02,;25.07,-34.79,;24.91,-36.32,;26.05,-37.35,;23.4,-36.64,;22.63,-35.31,;23.67,-34.16,;23.35,-32.66,;26.4,-32.47,;25.07,-31.7,;25.07,-30.16,;27.73,-31.7,;29.07,-32.47,;30.53,-31.98,;35.11,-31.48,;35.73,-30.07,;36.02,-32.72,;35.4,-34.13,;30.74,-23.95,;31.21,-22.48,;29.7,-22.81,)| | ||
| Structure | 
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