| Reaction Details |
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 | Report a problem with these data |
| Target | Gastric inhibitory polypeptide receptor |
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| Ligand | BDBM50459992 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_1768071 (CHEMBL4220183) |
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| EC50 | 0.812000±n/a nM |
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| Citation |  Knerr, PJ; Finan, B; Gelfanov, V; Perez-Tilve, D; Tschöp, MH; DiMarchi, RD Optimization of peptide-based polyagonists for treatment of diabetes and obesity. Bioorg Med Chem26:2873-2881 (2018) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Gastric inhibitory polypeptide receptor |
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| Name: | Gastric inhibitory polypeptide receptor |
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| Synonyms: | GIPR | GIPR_HUMAN | Gastric Inhibitory Polypeptide Receptor (GIPR) | Gastric inhibitory polypeptide receptor |
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| Type: | PROTEIN |
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| Mol. Mass.: | 53173.82 |
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| Organism: | Homo sapiens (Human) |
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| Description: | ChEMBL_1518286 |
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| Residue: | 466 |
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| Sequence: | MTTSPILQLLLRLSLCGLLLQRAETGSKGQTAGELYQRWERYRRECQETLAAAEPPSGLA
CNGSFDMYVCWDYAAPNATARASCPWYLPWHHHVAAGFVLRQCGSDGQWGLWRDHTQCEN
PEKNEAFLDQRLILERLQVMYTVGYSLSLATLLLALLILSLFRRLHCTRNYIHINLFTSF
MLRAAAILSRDRLLPRPGPYLGDQALALWNQALAACRTAQIVTQYCVGANYTWLLVEGVY
LHSLLVLVGGSEEGHFRYYLLLGWGAPALFVIPWVIVRYLYENTQCWERNEVKAIWWIIR
TPILMTILINFLIFIRILGILLSKLRTRQMRCRDYRLRLARSTLTLVPLLGVHEVVFAPV
TEEQARGALRFAKLGFEIFLSSFQGFLVSVLYCFINKEVQSEIRRGWHHCRLRRSLGEEQ
RQLPERAFRALPSGSGPGEVPTSRGLSSGTLPGPGNEASRELESYC
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| BDBM50459992 |
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| n/a |
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| Name | BDBM50459992 |
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| Synonyms: | CHEMBL4227180 |
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| Type | Small organic molecule |
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| Emp. Form. | C177H273N47O54 |
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| Mol. Mass. | 3923.344 |
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| SMILES | CCCCCCCCCCCCCCCC(=O)N[C@@H](CCC(=O)NCCCC[C@H](NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CO)NC(=O)[C@@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](NC(=O)CNC(=O)[C@H](CCC(N)=O)NC(=O)[C@@H](CO)NC(=O)[C@@H](N)Cc1cnc[nH]1)[C@@H](C)O)[C@@H](C)O)C(=O)N[C@@H](CO)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](C)C(=O)N[C@@H](C)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(O)=O)C(=O)NCC(=O)N[C@@H](CCCNC(N)=N)C(=O)NCC(N)=O)C(O)=O |r| |
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| Structure | 
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