Ki Summary

Reaction Details

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Target

Orotidine 5'-phosphate decarboxylase

Ligand

BDBM47402

Substrate/Competitor

n/a

Meas. Tech.

ChEMBL_1768163 (CHEMBL4220275)

64±n/a nM

Citation

Slusarczyk, M; Ferla, S; Brancale, A; McGuigan, C Synthesis and biological evaluation of 6-substituted-5-fluorouridine ProTides. Bioorg Med Chem26:551-565 (2018) [PubMed] Article

More Info.:

Get all data from this article, Assay Method

Orotidine 5'-phosphate decarboxylase

Name:

Orotidine 5'-phosphate decarboxylase

Synonyms:

Orotidine phosphate decarboxylase | PYRF_YEAST | URA3

Type:

PROTEIN

Mol. Mass.:

29241.18

Organism:

Saccharomyces cerevisiae

Description:

ChEMBL_639015

Residue:

267

Sequence:

MSKATYKERAATHPSPVAAKLFNIMHEKQTNLCASLDVRTTKELLELVEALGPKICLLKT
HVDILTDFSMEGTVKPLKALSAKYNFLLFEDRKFADIGNTVKLQYSAGVYRIAEWADITN
AHGVVGPGIVSGLKQAAEEVTKEPRGLLMLAELSCKGSLATGEYTKGTVDIAKSDKDFVI
GFIAQRDMGGRDEGYDWLIMTPGVGLDDKGDALGQQYRTVDDVVSTGSDIIIVGRGLFAK
GRDAKVEGERYRKAGWEAYLRRCGQQN

BDBM47402

n/a

Name

BDBM47402

Synonyms:

2-[(2R,3R,4S,5R)-3,4-dihydroxy-5-(hydroxymethyl)-2-oxolanyl]-1,2,4-triazine-3,5-dione | 2-[(2R,3R,4S,5R)-3,4-dihydroxy-5-(hydroxymethyl)oxolan-2-yl]-1,2,4-triazine-3,5-dione | 2-[(2R,3R,4S,5R)-3,4-dihydroxy-5-methylol-tetrahydrofuran-2-yl]-1,2,4-triazine-3,5-quinone | 2-[(2R,3R,4S,5R)-5-(hydroxymethyl)-3,4-bis(oxidanyl)oxolan-2-yl]-1,2,4-triazine-3,5-dione | 6-AZAURIDINE | MLS000028524 | SMR000058273 | cid_5901

Type

Small organic molecule

Emp. Form.

C8H11N3O6

Mol. Mass.

245.1894

SMILES

OC[C@H]1O[C@H]([C@H](O)[C@@H]1O)n1ncc(=O)[nH]c1=O

Structure