| Reaction Details |
|---|
 | Report a problem with these data |
| Target | Neutrophil elastase |
|---|
| Ligand | BDBM50023543 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | ChEMBL_63667 (CHEMBL675723) |
|---|
| IC50 | 360±n/a nM |
|---|
| Citation |  Miyano, M; Deason, JR; Nakao, A; Stealey, MA; Villamil, CI; Sohn, DD; Mueller, RA (Acyloxy)benzophenones and (acyloxy)-4-pyrones. A new class of inhibitors of human neutrophil elastase. J Med Chem31:1052-61 (1988) [PubMed] |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| Neutrophil elastase |
|---|
| Name: | Neutrophil elastase |
|---|
| Synonyms: | Bone marrow serine protease | Chymotrypsin | Coagulation factor X | ELA2 | ELANE | ELNE_HUMAN | Elastase | Elastase-2 | HLE | Human leukocyte elastase | Leukocyte elastase | Leukocyte elastase (HLE) | Medullasin | Neutrophil elastase | Neutrophil elastase (HNE) | Neutrophil elastase (NE) | PMN elastase | Thrombin | Trypsin |
|---|
| Type: | Enzyme |
|---|
| Mol. Mass.: | 28532.38 |
|---|
| Organism: | Homo sapiens (Human) |
|---|
| Description: | P08246 |
|---|
| Residue: | 267 |
|---|
| Sequence: | MTLGRRLACLFLACVLPALLLGGTALASEIVGGRRARPHAWPFMVSLQLRGGHFCGATLI
APNFVMSAAHCVANVNVRAVRVVLGAHNLSRREPTRQVFAVQRIFENGYDPVNLLNDIVI
LQLNGSATINANVQVAQLPAQGRRLGNGVQCLAMGWGLLGRNRGIASVLQELNVTVVTSL
CRRSNVCTLVRGRQAGVCFGDSGSPLVCNGLIHGIASFVRGGCASGLYPDAFAPVAQFVN
WIDSIIQRSEDNPCPHPRDPDPASRTH
|
|
|
|---|
| BDBM50023543 |
|---|
| n/a |
|---|
| Name | BDBM50023543 |
|---|
| Synonyms: | 2,2-Dimethyl-propionic acid 2,3-bis-(2,2-dimethyl-propionyloxy)-6-[3,4,5-tris-(2,2-dimethyl-propionyloxy)-benzoyl]-phenyl ester | CHEMBL275765 |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C43H58O13 |
|---|
| Mol. Mass. | 782.9128 |
|---|
| SMILES | CC(C)(C)C(=O)Oc1ccc(C(=O)c2cc(OC(=O)C(C)(C)C)c(OC(=O)C(C)(C)C)c(OC(=O)C(C)(C)C)c2)c(OC(=O)C(C)(C)C)c1OC(=O)C(C)(C)C |
|---|
| Structure | 
|
|---|
Search and Browse
