| Reaction Details |
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 | Report a problem with these data |
| Target | Muscarinic acetylcholine receptor M1 |
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| Ligand | BDBM50021847 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_138690 (CHEMBL747657) |
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| IC50 | 23±n/a nM |
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| Citation |  Eberlein, WG; Engel, WW; Trummlitz, G; Schmidt, G; Hammer, R Tricyclic compounds as selective antimuscarinics. 2. Structure-activity relationships of M1-selective antimuscarinics related to pirenzepine. J Med Chem31:1169-74 (1988) [PubMed] |
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| More Info.: | Get all data from this article, Assay Method |
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| Muscarinic acetylcholine receptor M1 |
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| Name: | Muscarinic acetylcholine receptor M1 |
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| Synonyms: | ACM1_RAT | Cholinergic, muscarinic M1 | Chrm-1 | Chrm1 | cholinergic receptor, muscarinic 1 |
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| Type: | Enzyme Catalytic Domain |
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| Mol. Mass.: | 51390.46 |
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| Organism: | RAT |
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| Description: | P08482 |
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| Residue: | 460 |
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| Sequence: | MNTSVPPAVSPNITVLAPGKGPWQVAFIGITTGLLSLATVTGNLLVLISFKVNTELKTVN
NYFLLSLACADLIIGTFSMNLYTTYLLMGHWALGTLACDLWLALDYVASNASVMNLLLIS
FDRYFSVTRPLSYRAKRTPRRAALMIGLAWLVSFVLWAPAILFWQYLVGERTVLAGQCYI
QFLSQPIITFGTAMAAFYLPVTVMCTLYWRIYRETENRARELAALQGSETPGKGGGSSSS
SERSQPGAEGSPESPPGRCCRCCRAPRLLQAYSWKEEEEEDEGSMESLTSSEGEEPGSEV
VIKMPMVDSEAQAPTKQPPKSSPNTVKRPTKKGRDRGGKGQKPRGKEQLAKRKTFSLVKE
KKAARTLSAILLAFILTWTPYNIMVLVSTFCKDCVPETLWELGYWLCYVNSTVNPMCYAL
CNKAFRDTFRLLLLCRWDKRRWRKIPKRPGSVHRTPSRQC
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| BDBM50021847 |
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| n/a |
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| Name | BDBM50021847 |
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| Synonyms: | 5-[2-(4-Methyl-piperazin-1-yl)-acetyl]-5,10-dihydro-dibenzo[b,e][1,4]diazepin-11-one | CHEMBL276771 |
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| Type | Small organic molecule |
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| Emp. Form. | C20H22N4O2 |
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| Mol. Mass. | 350.4143 |
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| SMILES | CN1CCN(CC(=O)N2c3ccccc3NC(=O)c3ccccc23)CC1 |
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| Structure | 
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