| Reaction Details |
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 | Report a problem with these data |
| Target | Hydroxycarboxylic acid receptor 2 |
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| Ligand | BDBM50462122 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_1772779 (CHEMBL4229771) |
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| EC50 | 1200±n/a nM |
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| Citation |  Ramesh, R; Reddy, DS Quest for Novel Chemical Entities through Incorporation of Silicon in Drug Scaffolds. J Med Chem61:3779-3798 (2018) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Hydroxycarboxylic acid receptor 2 |
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| Name: | Hydroxycarboxylic acid receptor 2 |
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| Synonyms: | Gpr109 | Gpr109a | Gpr109b | HCAR2_RAT | HM74 nicotinic acid GPCR | Hcar2 | Niacr1 | Pumag |
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| Type: | PROTEIN |
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| Mol. Mass.: | 41476.06 |
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| Organism: | Rattus norvegicus |
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| Description: | ChEMBL_820675 |
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| Residue: | 360 |
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| Sequence: | MSKQNHFLVINGKNCCVFRDENIAKVLPPVLGLEFVFGLLGNGLALWIFCFHLKSWKSSR
IFLFNLAVADFLLIICLPFLTDNYVQNWDWRFGSIPCRVMLFMLAMNRQGSIIFLTVVAV
DRYFRVVHPHHFLNKISNRTAAIISCFLWGITIGLTVHLLYTDMMTRNGDANLCSSFSIC
YTFRWHDAMFLLEFFLPLGIILFCSGRIIWSLRQRQMDRHVKIKRAINFIMVVAIVFVIC
FLPSVAVRIRIFWLLYKHNVRNCDIYSSVDLAFFTTLSFTYMNSMLDPVVYYFSSPSFPN
FFSTCINRCLRRKTLGEPDNNRSTSVELTGDPSTIRSIPGALMTDPSEPGSPPYLASTSR
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| BDBM50462122 |
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| n/a |
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| Name | BDBM50462122 |
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| Synonyms: | CHEMBL4240407 |
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| Type | Small organic molecule |
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| Emp. Form. | C28H33ClN4O5SSi |
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| Mol. Mass. | 601.189 |
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| SMILES | [#6]-[#6]-[#8]-c1cc(Cl)c(cc1-[#7]-1-[#6]-[#6]-[#8]-[#6]-[#6]-1)-[#6](=O)-[#7]-[#6](=O)-[#7]-c1nc2-[#6]-[#6][Si;v4]([#6])([#6]-c2s1)c1ccc(-[#8]-[#6])cc1 |
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| Structure | 
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