| Reaction Details |
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 | Report a problem with these data |
| Target | Myc proto-oncogene protein |
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| Ligand | BDBM50463131 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_1777746 (CHEMBL4234738) |
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| IC50 | 7000±n/a nM |
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| Citation |  Jacob, NT; Miranda, PO; Shirey, RJ; Gautam, R; Zhou, B; de Orbe Izquierdo, ME; Hixon, MS; Hart, JR; Ueno, L; Vogt, PK; Janda, KD Synthetic molecules for disruption of the MYC protein-protein interface. Bioorg Med Chem26:4234-4239 (2018) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Myc proto-oncogene protein |
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| Name: | Myc proto-oncogene protein |
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| Synonyms: | BHLHE39 | Class E basic helix-loop-helix protein 39 | MYC | MYC_HUMAN | Proto-oncogene c-Myc | Transcription factor p64 |
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| Type: | PROTEIN |
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| Mol. Mass.: | 48794.95 |
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| Organism: | Homo sapiens (Human) |
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| Description: | ChEMBL_935266 |
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| Residue: | 439 |
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| Sequence: | MPLNVSFTNRNYDLDYDSVQPYFYCDEEENFYQQQQQSELQPPAPSEDIWKKFELLPTPP
LSPSRRSGLCSPSYVAVTPFSLRGDNDGGGGSFSTADQLEMVTELLGGDMVNQSFICDPD
DETFIKNIIIQDCMWSGFSAAAKLVSEKLASYQAARKDSGSPNPARGHSVCSTSSLYLQD
LSAAASECIDPSVVFPYPLNDSSSPKSCASQDSSAFSPSSDSLLSSTESSPQGSPEPLVL
HEETPPTTSSDSEEEQEDEEEIDVVSVEKRQAPGKRSESGSPSAGGHSKPPHSPLVLKRC
HVSTHQHNYAAPPSTRKDYPAAKRVKLDSVRVLRQISNNRKCTSPRSSDTEENVKRRTHN
VLERQRRNELKRSFFALRDQIPELENNEKAPKVVILKKATAYILSVQAEEQKLISEEDLL
RKRREQLKHKLEQLRNSCA
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| BDBM50463131 |
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| n/a |
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| Name | BDBM50463131 |
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| Synonyms: | CHEMBL4248559 |
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| Type | Small organic molecule |
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| Emp. Form. | C22H14N4O2 |
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| Mol. Mass. | 366.3722 |
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| SMILES | NC(=O)c1ccc(cc1)-c1cc(nc(n1)-c1ccco1)-c1ccc(cc1)C#N |
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| Structure | 
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