| Reaction Details |
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 | Report a problem with these data |
| Target | Dipeptidyl peptidase 4 |
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| Ligand | BDBM50463326 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_1778017 (CHEMBL4235009) |
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| IC50 | 1780±n/a nM |
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| Citation |  Kuranov, SO; Tsypysheva, IP; Khvostov, MV; Zainullina, LF; Borisevich, SS; Vakhitova, YV; Luzina, OA; Salakhutdinov, NF Synthesis and evaluation of camphor and cytisine-based cyanopyrrolidines as DPP-IV inhibitors for the treatment of type 2 diabetes mellitus. Bioorg Med Chem26:4402-4409 (2018) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Dipeptidyl peptidase 4 |
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| Name: | Dipeptidyl peptidase 4 |
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| Synonyms: | ADABP | ADCP2 | Adenosine deaminase complexing protein 2 | CD26 | CD_antigen=CD26 | DPP IV | DPP4 | DPP4_HUMAN | DPPIV | Dipeptidyl peptidase 4 (DDP-IV) | Dipeptidyl peptidase 4 (DPP IV) | Dipeptidyl peptidase 4 (DPP-4) | Dipeptidyl peptidase 4 (DPP4) | Dipeptidyl peptidase 4 (DPPIV) | Dipeptidyl peptidase 4 membrane form | Dipeptidyl peptidase 4 soluble form | Dipeptidyl peptidase IV | Dipeptidyl peptidase IV (DDP-4) | Dipeptidyl peptidase IV (DDP-IV) | Dipeptidyl peptidase IV (DPP IV) | Dipeptidyl peptidase IV membrane form | Dipeptidyl peptidase IV soluble form | Dipeptidyl peptidase-IV (DPP-4) | Dipeptidyl peptidase-IV (DPP-IV) | T-cell activation antigen CD26 | TP103 |
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| Type: | Enzyme |
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| Mol. Mass.: | 88271.01 |
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| Organism: | Homo sapiens (Human) |
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| Description: | P27487 |
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| Residue: | 766 |
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| Sequence: | MKTPWKVLLGLLGAAALVTIITVPVVLLNKGTDDATADSRKTYTLTDYLKNTYRLKLYSL
RWISDHEYLYKQENNILVFNAEYGNSSVFLENSTFDEFGHSINDYSISPDGQFILLEYNY
VKQWRHSYTASYDIYDLNKRQLITEERIPNNTQWVTWSPVGHKLAYVWNNDIYVKIEPNL
PSYRITWTGKEDIIYNGITDWVYEEEVFSAYSALWWSPNGTFLAYAQFNDTEVPLIEYSF
YSDESLQYPKTVRVPYPKAGAVNPTVKFFVVNTDSLSSVTNATSIQITAPASMLIGDHYL
CDVTWATQERISLQWLRRIQNYSVMDICDYDESSGRWNCLVARQHIEMSTTGWVGRFRPS
EPHFTLDGNSFYKIISNEEGYRHICYFQIDKKDCTFITKGTWEVIGIEALTSDYLYYISN
EYKGMPGGRNLYKIQLSDYTKVTCLSCELNPERCQYYSVSFSKEAKYYQLRCSGPGLPLY
TLHSSVNDKGLRVLEDNSALDKMLQNVQMPSKKLDFIILNETKFWYQMILPPHFDKSKKY
PLLLDVYAGPCSQKADTVFRLNWATYLASTENIIVASFDGRGSGYQGDKIMHAINRRLGT
FEVEDQIEAARQFSKMGFVDNKRIAIWGWSYGGYVTSMVLGSGSGVFKCGIAVAPVSRWE
YYDSVYTERYMGLPTPEDNLDHYRNSTVMSRAENFKQVEYLLIHGTADDNVHFQQSAQIS
KALVDVGVDFQAMWYTDEDHGIASSTAHQHIYTHMSHFIKQCFSLP
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| BDBM50463326 |
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| n/a |
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| Name | BDBM50463326 |
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| Synonyms: | CHEMBL4242321 |
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| Type | Small organic molecule |
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| Emp. Form. | C17H27N3O |
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| Mol. Mass. | 289.4158 |
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| SMILES | [H][C@]12CC[C@](C)([C@H](C1)NCC(=O)N1CCC[C@H]1C#N)C2(C)C |r,THB:8:6:2.3:19| |
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| Structure | 
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