| Reaction Details |
|---|
 | Report a problem with these data |
| Target | Tyrosyl-DNA phosphodiesterase 1 |
|---|
| Ligand | BDBM50463372 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | ChEMBL_1778170 (CHEMBL4235162) |
|---|
| IC50 | 150±n/a nM |
|---|
| Citation |  Zakharova, O; Luzina, O; Zakharenko, A; Sokolov, D; Filimonov, A; Dyrkheeva, N; Chepanova, A; Ilina, E; Ilyina, A; Klabenkova, K; Chelobanov, B; Stetsenko, D; Zafar, A; Eurtivong, C; Reynisson, J; Volcho, K; Salakhutdinov, N; Lavrik, O Synthesis and evaluation of aryliden- and hetarylidenfuranone derivatives of usnic acid as highly potent Tdp1 inhibitors. Bioorg Med Chem26:4470-4480 (2018) [PubMed] Article |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| Tyrosyl-DNA phosphodiesterase 1 |
|---|
| Name: | Tyrosyl-DNA phosphodiesterase 1 |
|---|
| Synonyms: | TDP1 | TYDP1_HUMAN | Tyrosyl-DNA phosphodiesterase 1 | Tyrosyl-DNA phosphodiesterase 1 (TDP1) |
|---|
| Type: | Enzyme |
|---|
| Mol. Mass.: | 68430.66 |
|---|
| Organism: | Homo sapiens (Human) |
|---|
| Description: | Q9NUW8 |
|---|
| Residue: | 608 |
|---|
| Sequence: | MSQEGDYGRWTISSSDESEEEKPKPDKPSTSSLLCARQGAANEPRYTCSEAQKAAHKRKI
SPVKFSNTDSVLPPKRQKSGSQEDLGWCLSSSDDELQPEMPQKQAEKVVIKKEKDISAPN
DGTAQRTENHGAPACHRLKEEEDEYETSGEGQDIWDMLDKGNPFQFYLTRVSGVKPKYNS
GALHIKDILSPLFGTLVSSAQFNYCFDVDWLVKQYPPEFRKKPILLVHGDKREAKAHLHA
QAKPYENISLCQAKLDIAFGTHHTKMMLLLYEEGLRVVIHTSNLIHADWHQKTQGIWLSP
LYPRIADGTHKSGESPTHFKADLISYLMAYNAPSLKEWIDVIHKHDLSETNVYLIGSTPG
RFQGSQKDNWGHFRLKKLLKDHASSMPNAESWPVVGQFSSVGSLGADESKWLCSEFKESM
LTLGKESKTPGKSSVPLYLIYPSVENVRTSLEGYPAGGSLPYSIQTAEKQNWLHSYFHKW
SAETSGRSNAMPHIKTYMRPSPDFSKIAWFLVTSANLSKAAWGALEKNGTQLMIRSYELG
VLFLPSAFGLDSFKVKQKFFAGSQEPMATFPVPYDLPPELYGSKDRPWIWNIPYVKAPDT
HGNMWVPS
|
|
|
|---|
| BDBM50463372 |
|---|
| n/a |
|---|
| Name | BDBM50463372 |
|---|
| Synonyms: | CHEMBL3356739 |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C25H17BrO7 |
|---|
| Mol. Mass. | 509.302 |
|---|
| SMILES | CC(=O)C1=C(O)C=C2Oc3c4C(=O)\C(Oc4c(C)c(O)c3[C@@]2(C)C1=O)=C\c1ccc(Br)cc1 |r,c:3,t:6| |
|---|
| Structure | 
|
|---|
Search and Browse
