| Reaction Details |
|---|
 | Report a problem with these data |
| Target | Serine/threonine-protein kinase receptor R3 |
|---|
| Ligand | BDBM50463510 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | ChEMBL_1778480 (CHEMBL4235472) |
|---|
| Kd | 420±n/a nM |
|---|
| Citation |  Hudson, L; Mui, J; Vázquez, S; Carvalho, DM; Williams, E; Jones, C; Bullock, AN; Hoelder, S Novel Quinazolinone Inhibitors of ALK2 Flip between Alternate Binding Modes: Structure-Activity Relationship, Structural Characterization, Kinase Profiling, and Cellular Proof of Concept. J Med Chem61:7261-7272 (2018) [PubMed] Article |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| Serine/threonine-protein kinase receptor R3 |
|---|
| Name: | Serine/threonine-protein kinase receptor R3 |
|---|
| Synonyms: | ACVL1_HUMAN | ACVRL1 | ACVRLK1 | ALK1 | Activin receptor-like kinase 1 (ALK-1) | Serine/threonine-protein kinase receptor R3 (ALK1) |
|---|
| Type: | Enzyme |
|---|
| Mol. Mass.: | 56134.46 |
|---|
| Organism: | Homo sapiens (Human) |
|---|
| Description: | P37023 |
|---|
| Residue: | 503 |
|---|
| Sequence: | MTLGSPRKGLLMLLMALVTQGDPVKPSRGPLVTCTCESPHCKGPTCRGAWCTVVLVREEG
RHPQEHRGCGNLHRELCRGRPTEFVNHYCCDSHLCNHNVSLVLEATQPPSEQPGTDGQLA
LILGPVLALLALVALGVLGLWHVRRRQEKQRGLHSELGESSLILKASEQGDSMLGDLLDS
DCTTGSGSGLPFLVQRTVARQVALVECVGKGRYGEVWRGLWHGESVAVKIFSSRDEQSWF
RETEIYNTVLLRHDNILGFIASDMTSRNSSTQLWLITHYHEHGSLYDFLQRQTLEPHLAL
RLAVSAACGLAHLHVEIFGTQGKPAIAHRDFKSRNVLVKSNLQCCIADLGLAVMHSQGSD
YLDIGNNPRVGTKRYMAPEVLDEQIRTDCFESYKWTDIWAFGLVLWEIARRTIVNGIVED
YRPPFYDVVPNDPSFEDMKKVVCVDQQTPTIPNRLAADPVLSGLAQMMRECWYPNPSARL
TALRIKKTLQKISNSPEKPKVIQ
|
|
|
|---|
| BDBM50463510 |
|---|
| n/a |
|---|
| Name | BDBM50463510 |
|---|
| Synonyms: | CHEMBL4244382 |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C27H22N4O2 |
|---|
| Mol. Mass. | 434.4892 |
|---|
| SMILES | O=c1n(cnc2ccc(cc12)-c1ccnc2ccccc12)-c1ccc(cc1)N1CCOCC1 |
|---|
| Structure | 
|
|---|
Search and Browse
