Ki Summary

Reaction Details

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Target

C-C chemokine receptor type 6

Ligand

BDBM50463601

Substrate/Competitor

n/a

Meas. Tech.

ChEMBL_1778803 (CHEMBL4235795)

IC50

31±n/a nM

Citation

Tawaraishi, T; Sakauchi, N; Hidaka, K; Yoshikawa, K; Okui, T; Kuno, H; Chisaki, I; Aso, K Identification of a novel series of potent and selective CCR6 inhibitors as biological probes. Bioorg Med Chem Lett28:3067-3072 (2018) [PubMed] Article

More Info.:

Get all data from this article, Assay Method

C-C chemokine receptor type 6

Name:

C-C chemokine receptor type 6

Synonyms:

Type:

Enzyme

Mol. Mass.:

42510.84

Organism:

Homo sapiens (Human)

Description:

P51684

Residue:

374

Sequence:

MSGESMNFSDVFDSSEDYFVSVNTSYYSVDSEMLLCSLQEVRQFSRLFVPIAYSLICVFG
LLGNILVVITFAFYKKARSMTDVYLLNMAIADILFVLTLPFWAVSHATGAWVFSNATCKL
LKGIYAINFNCGMLLLTCISMDRYIAIVQATKSFRLRSRTLPRSKIICLVVWGLSVIISS
STFVFNQKYNTQGSDVCEPKYQTVSEPIRWKLLMLGLELLFGFFIPLMFMIFCYTFIVKT
LVQAQNSKRHKAIRVIIAVVLVFLACQIPHNMVLLVTAANLGKMNRSCQSEKLIGYTKTV
TEVLAFLHCCLNPVLYAFIGQKFRNYFLKILKDLWCVRRKYKSSGFSCAGRYSENISRQT
SETADNDNASSFTM

BDBM50463601

n/a

Name

BDBM50463601

Synonyms:

CHEMBL4239428

Type

Small organic molecule

Emp. Form.

C25H22F3N3O2S

Mol. Mass.

485.521

SMILES

FC(F)(F)c1ccc(N[C@H]2CC[C@@H](CC2)S(=O)(=O)c2ccc(cc2)-c2cccc(c2)C#N)nc1 |r,wU:12.15,wD:9.8,(22.76,-58.96,;24.1,-58.19,;23.32,-56.86,;24.86,-56.86,;25.43,-58.96,;26.76,-58.19,;28.09,-58.96,;28.1,-60.51,;29.44,-61.27,;30.77,-60.5,;32.1,-61.28,;33.43,-60.52,;33.43,-58.98,;32.1,-58.2,;30.76,-58.97,;34.77,-58.21,;33.99,-56.86,;35.53,-56.86,;36.1,-58.98,;36.09,-60.52,;37.42,-61.29,;38.76,-60.53,;38.75,-58.98,;37.42,-58.21,;40.09,-61.3,;40.08,-62.84,;41.41,-63.61,;42.75,-62.84,;42.74,-61.29,;41.41,-60.53,;44.08,-60.52,;45.4,-59.74,;26.76,-61.28,;25.43,-60.51,)|

Structure