| Reaction Details |
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 | Report a problem with these data |
| Target | Hematopoietic prostaglandin D synthase |
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| Ligand | BDBM50463700 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_1779053 (CHEMBL4236045) |
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| IC50 | 10.0±n/a nM |
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| Citation |  Vaz, RJ; Li, Y; Munson, M; Elliot, M; Thurairatnam, S Amelioration of mechanism-based inactivation of CYP3A4 by a H-PGDS inhibitor. Bioorg Med Chem Lett28:3046-3049 (2018) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Hematopoietic prostaglandin D synthase |
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| Name: | Hematopoietic prostaglandin D synthase |
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| Synonyms: | GSTS | Glutathione-dependent PGD synthetase | Glutathione-requiring prostaglandin D synthase | H-PGDS | HPGDS | HPGDS_HUMAN | Hematopoietic prostaglandin D synthase | Hematopoietic prostaglandin D synthase (H-PGDS) | Hematopoietic prostaglandin D synthase (HPGDS) | PGDS | PTGDS2 | Prostaglandin D | Prostaglandin D Synthase |
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| Type: | Enzyme |
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| Mol. Mass.: | 23341.07 |
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| Organism: | Homo sapiens (Human) |
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| Description: | The protein was expressed in E. coli strain BL21(DE3) with an N-terminal 6-His tag. |
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| Residue: | 199 |
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| Sequence: | MPNYKLTYFNMRGRAEIIRYIFAYLDIQYEDHRIEQADWPEIKSTLPFGKIPILEVDGLT
LHQSLAIARYLTKNTDLAGNTEMEQCHVDAIVDTLDDFMSCFPWAEKKQDVKEQMFNELL
TYNAPHLMQDLDTYLGGREWLIGNSVTWADFYWEICSTTLLVFKPDLLDNHPRLVTLRKK
VQAIPAVANWIKRRPQTKL
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| BDBM50463700 |
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| n/a |
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| Name | BDBM50463700 |
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| Synonyms: | CHEMBL4239352 |
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| Type | Small organic molecule |
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| Emp. Form. | C20H14F3N5O |
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| Mol. Mass. | 397.3533 |
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| SMILES | Cc1nc(ncc1C(=O)Nn1ccc2c(cccc12)C(F)(F)F)-c1ccccn1 |
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| Structure | 
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