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| Reaction Details | |||
|---|---|---|---|
 | Report a problem with these data | ||
| Target | Tyrosine-protein kinase JAK1 | ||
| Ligand | BDBM50463839 | ||
| Substrate/Competitor | n/a | ||
| Meas. Tech. | ChEMBL_1779476 (CHEMBL4236468) | ||
| IC50 | 12±n/a nM | ||
| Citation |  Hamaguchi, H; Amano, Y; Moritomo, A; Shirakami, S; Nakajima, Y; Nakai, K; Nomura, N; Ito, M; Higashi, Y; Inoue, T Discovery and structural characterization of peficitinib (ASP015K) as a novel and potent JAK inhibitor. Bioorg Med Chem26:4971-4983 (2018) [PubMed] Article | ||
| More Info.: | Get all data from this article, Assay Method | ||
| Tyrosine-protein kinase JAK1 | |||
| Name: | Tyrosine-protein kinase JAK1 | ||
| Synonyms: | JAK-1 | JAK1 | JAK1A | JAK1B | JAK1_HUMAN | Janus kinase 1 | Janus kinase 1 (JAK1) | Janus kinase 1 JAK1 | ||
| Type: | Protein | ||
| Mol. Mass.: | 133293.73 | ||
| Organism: | Homo sapiens (Human) | ||
| Description: | P23458 | ||
| Residue: | 1154 | ||
| Sequence: |
| ||
| BDBM50463839 | |||
| n/a | |||
| Name | BDBM50463839 | ||
| Synonyms: | CHEMBL4249444 | ||
| Type | Small organic molecule | ||
| Emp. Form. | C18H22N4O | ||
| Mol. Mass. | 310.3935 | ||
| SMILES | NC(=O)c1cnc2[nH]ccc2c1NC1C2CC3CC(C2)CC1C3 |TLB:19:18:22:15.14.13,19:14:17.18.20:22,THB:13:14:17:20.21.22,13:21:17:15.19.14,12:13:17.18.20:22,(38.01,-5.93,;36.68,-6.7,;36.68,-8.24,;35.34,-5.93,;35.34,-4.38,;34,-3.62,;32.66,-4.4,;31.2,-3.93,;30.3,-5.18,;31.21,-6.42,;32.67,-5.94,;34.01,-6.71,;34.01,-8.25,;32.72,-9.1,;32.7,-10.64,;31.3,-10.99,;29.97,-10.5,;28.77,-11.78,;30.27,-11.37,;31.7,-11.93,;30.27,-9.77,;31.31,-8.53,;29.96,-9,)| | ||
| Structure | 
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