| Reaction Details |
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 | Report a problem with these data |
| Target | Transient receptor potential cation channel subfamily V member 2 |
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| Ligand | BDBM50463953 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_1779721 (CHEMBL4236713) |
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| IC50 | 1400±n/a nM |
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| Citation |  Schiano Moriello, A; López Chinarro, S; Novo Fernández, O; Eras, J; Amodeo, P; Canela-Garayoa, R; Vitale, RM; Di Marzo, V; De Petrocellis, L Elongation of the Hydrophobic Chain as a Molecular Switch: Discovery of Capsaicin Derivatives and Endogenous Lipids as Potent Transient Receptor Potential Vanilloid Channel 2 Antagonists. J Med Chem61:8255-8281 (2018) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Transient receptor potential cation channel subfamily V member 2 |
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| Name: | Transient receptor potential cation channel subfamily V member 2 |
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| Synonyms: | Sac2b | TRPV2_RAT | Transient receptor potential cation channel subfamily V member 2 | Trpv2 | Vanilloid receptor | Vrl1 |
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| Type: | PROTEIN |
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| Mol. Mass.: | 86707.60 |
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| Organism: | Rattus norvegicus |
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| Description: | ChEMBL_768011 |
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| Residue: | 761 |
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| Sequence: | MTSASSPPAFRLETSDGDEEGNAEVNKGKQEPPPMESPFQREDRNSSPQIKVNLNFIKRP
PKNTSAPSQQEPDRFDRDRLFSVVSRGVPEELTGLLEYLRWNSKYLTDSAYTEGSTGKTC
LMKAVLNLQDGVNACIMPLLQIDKDSGNPKLLVNAQCTDEFYQGHSALHIAIEKRSLQCV
KLLVENGADVHLRACGRFFQKHQGTCFYFGELPLSLAACTKQWDVVTYLLENPHQPASLE
ATDSLGNTVLHALVMIADNSPENSALVIHMYDGLLQMGARLCPTVQLEEISNHQGLTPLK
LAAKEGKIEIFRHILQREFSGPYQPLSRKFTEWCYGPVRVSLYDLSSVDSWEKNSVLEII
AFHCKSPNRHRMVVLEPLNKLLQEKWDRLVSRFFFNFACYLVYMFIFTVVAYHQPSLDQP
AIPSSKATFGESMLLLGHILILLGGIYLLLGQLWYFWRRRLFIWISFMDSYFEILFLLQA
LLTVLSQVLRFMETEWYLPLLVLSLVLGWLNLLYYTRGFQHTGIYSVMIQKVILRDLLRF
LLVYLVFLFGFAVALVSLSREARSPKAPEDNNSTVTEQPTVGQEEEPAPYRSILDASLEL
FKFTIGMGELAFQEQLRFRGVVLLLLLAYVLLTYVLLLNMLIALMSETVNHVADNSWSIW
KLQKAISVLEMENGYWWCRRKKHREGRLLKVGTRGDGTPDERWCFRVEEVNWAAWEKTLP
TLSEDPSGPGITGNKKNPTSKPGKNSASEEDHLPLQVLQSP
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| BDBM50463953 |
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| n/a |
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| Name | BDBM50463953 |
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| Synonyms: | CHEMBL4247743 |
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| Type | Small organic molecule |
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| Emp. Form. | C29H49F3N2O5S |
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| Mol. Mass. | 594.77 |
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| SMILES | OC(=O)C(F)(F)F.CCCCCCCCCCCCCCCCSC[C@H](N)C(=O)NCc1ccc(O)c(OC)c1 |r| |
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| Structure | 
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