Reaction Details |
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Target | Carbonic anhydrase 12 |
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Ligand | BDBM50465663 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEMBL_1785327 (CHEMBL4256844) |
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Ki | 3.0±n/a nM |
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Citation | Bozdag, M; Carta, F; Ceruso, M; Ferraroni, M; McDonald, PC; Dedhar, S; Supuran, CT Discovery of 4-Hydroxy-3-(3-(phenylureido)benzenesulfonamides as SLC-0111 Analogues for the Treatment of Hypoxic Tumors Overexpressing Carbonic Anhydrase IX. J Med Chem61:6328-6338 (2018) [PubMed] Article |
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More Info.: | Get all data from this article, Assay Method |
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Carbonic anhydrase 12 |
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Name: | Carbonic anhydrase 12 |
Synonyms: | CA-XII | CA12 | CAH12_HUMAN | Carbonate dehydratase XII | Carbonic anhydrase | Carbonic anhydrase 12 (CA XII) | Carbonic anhydrase XII | Carbonic anhydrase XII (CA XII) | Carbonic anhydrase XII (CAXII) | Tumor antigen HOM-RCC-3.1.3 |
Type: | Enzyme |
Mol. Mass.: | 39456.00 |
Organism: | Homo sapiens (Human) |
Description: | Catalytic domain of human cloned isozyme was used in the assay |
Residue: | 354 |
Sequence: | MPRRSLHAAAVLLLVILKEQPSSPAPVNGSKWTYFGPDGENSWSKKYPSCGGLLQSPIDL
HSDILQYDASLTPLEFQGYNLSANKQFLLTNNGHSVKLNLPSDMHIQGLQSRYSATQLHL
HWGNPNDPHGSEHTVSGQHFAAELHIVHYNSDLYPDASTASNKSEGLAVLAVLIEMGSFN
PSYDKIFSHLQHVKYKGQEAFVPGFNIEELLPERTAEYYRYRGSLTTPPCNPTVLWTVFR
NPVQISQEQLLALETALYCTHMDDPSPREMINNFRQVQKFDERLVYTSFSQVQVCTAAGL
SLGIILSLALAGILGICIVVVVSIWLFRRKSIKKGDNKGVIYKPATKMETEAHA
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BDBM50465663 |
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n/a |
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Name | BDBM50465663 |
Synonyms: | CHEMBL4292591 |
Type | Small organic molecule |
Emp. Form. | C13H12ClN3O4S |
Mol. Mass. | 341.77 |
SMILES | NS(=O)(=O)c1ccc(O)c(NC(=O)Nc2ccccc2Cl)c1 |
Structure |
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