Reaction Details |
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Target | Estradiol 17-beta-dehydrogenase 2 |
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Ligand | BDBM50466019 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEMBL_1789617 (CHEMBL4261351) |
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IC50 | 58±n/a nM |
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Citation | Siebenbuerger, L; Hernandez-Olmos, V; Abdelsamie, AS; Frotscher, M; van Koppen, CJ; Marchais-Oberwinkler, S; Scheuer, C; Laschke, MW; Menger, MD; Boerger, C; Hartmann, RW Highly Potent 17?-HSD2 Inhibitors with a Promising Pharmacokinetic Profile for Targeted Osteoporosis Therapy. J Med Chem61:10724-10738 (2018) [PubMed] Article |
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More Info.: | Get all data from this article, Assay Method |
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Estradiol 17-beta-dehydrogenase 2 |
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Name: | Estradiol 17-beta-dehydrogenase 2 |
Synonyms: | 17-beta-HSD 2 | 17-beta-hydroxysteroid dehydrogenase type 2 | DHB2_MOUSE | Edh17b2 | Hsd17b2 | Testosterone 17-beta-dehydrogenase |
Type: | PROTEIN |
Mol. Mass.: | 41847.95 |
Organism: | Mus musculus |
Description: | ChEMBL_104366 |
Residue: | 381 |
Sequence: | MSPFASESAWLCLAAAAVLGGTLLCGCRSGRQLRSQAVCLAGLWGGACLLSLSLLCTLFL
LSVACFLLLYMSSSDQDLLPVDQKAVLVTGADSGFGHGLAKHLDKLGFTVFAGVLDKEGP
GAEELRKHCSERLSVLQMDVTKPEQIKDAHSKVTEKIQDKGLWAVVNNAGVFHLPIDGEL
IPMSIYRKCMAVNFFGTVEVTKAFLPLLRKSKGRLVNVSSMGGTVPLQMTSAYAATKAAL
TMFSTIIRQELDKWGVKVVTIKPGGFKTNITGSQDIWDKMEKEILDHFSKDIQENYGQDY
VHTQKLIIPTLKERSNPDITPVLRDIQHAISARNPSSFYYPGRMAYLWVCLAAYCPTSLL
DYVIKKGFYPQPTPRALRTVH
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BDBM50466019 |
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n/a |
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Name | BDBM50466019 |
Synonyms: | CHEMBL4286251 |
Type | Small organic molecule |
Emp. Form. | C19H13F3O3S |
Mol. Mass. | 378.365 |
SMILES | Cc1cc(cc(C)c1O)-c1ccc(s1)C(=O)c1cc(F)c(F)c(O)c1F |
Structure |
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