| Reaction Details |
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 | Report a problem with these data |
| Target | Neutrophil elastase |
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| Ligand | BDBM50120437 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_1793170 (CHEMBL4265089) |
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| IC50 | 0.065000±n/a nM |
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| Citation |  Crocetti, L; Giovannoni, MP; Schepetkin, IA; Quinn, MT; Khlebnikov, AI; Cantini, N; Guerrini, G; Iacovone, A; Teodori, E; Vergelli, C 1H-pyrrolo[2,3-b]pyridine: A new scaffold for human neutrophil elastase (HNE) inhibitors. Bioorg Med Chem26:5583-5595 (2018) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Neutrophil elastase |
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| Name: | Neutrophil elastase |
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| Synonyms: | Bone marrow serine protease | Chymotrypsin | Coagulation factor X | ELA2 | ELANE | ELNE_HUMAN | Elastase | Elastase-2 | HLE | Human leukocyte elastase | Leukocyte elastase | Leukocyte elastase (HLE) | Medullasin | Neutrophil elastase | Neutrophil elastase (HNE) | Neutrophil elastase (NE) | PMN elastase | Thrombin | Trypsin |
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| Type: | Enzyme |
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| Mol. Mass.: | 28532.38 |
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| Organism: | Homo sapiens (Human) |
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| Description: | P08246 |
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| Residue: | 267 |
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| Sequence: | MTLGRRLACLFLACVLPALLLGGTALASEIVGGRRARPHAWPFMVSLQLRGGHFCGATLI
APNFVMSAAHCVANVNVRAVRVVLGAHNLSRREPTRQVFAVQRIFENGYDPVNLLNDIVI
LQLNGSATINANVQVAQLPAQGRRLGNGVQCLAMGWGLLGRNRGIASVLQELNVTVVTSL
CRRSNVCTLVRGRQAGVCFGDSGSPLVCNGLIHGIASFVRGGCASGLYPDAFAPVAQFVN
WIDSIIQRSEDNPCPHPRDPDPASRTH
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| BDBM50120437 |
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| n/a |
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| Name | BDBM50120437 |
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| Synonyms: | CHEMBL3617973 |
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| Type | Small organic molecule |
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| Emp. Form. | C22H17F3N4O3S |
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| Mol. Mass. | 474.456 |
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| SMILES | CN1[C@@H](C(C#N)=C(C)N(C1=O)c1cccc(c1)C(F)(F)F)c1ccc(cc1S(C)(=O)=O)C#N |r,t:5| |
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| Structure | 
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