| Reaction Details |
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 | Report a problem with these data |
| Target | Casein kinase II subunit alpha/beta |
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| Ligand | BDBM50466851 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_1794560 (CHEMBL4266677) |
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| IC50 | 32340±n/a nM |
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| Citation |  Jarhad, DB; Mashelkar, KK; Kim, HR; Noh, M; Jeong, LS Dual-Specificity Tyrosine Phosphorylation-Regulated Kinase 1A (DYRK1A) Inhibitors as Potential Therapeutics. J Med Chem61:9791-9810 (2018) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Casein kinase II subunit alpha/beta |
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| Name: | Casein kinase II subunit alpha/beta |
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| Synonyms: | Casein kinase 2 |
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| Type: | n/a |
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| Mol. Mass.: | n/a |
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| Description: | ASSAY_ID of ChEMBL is 902795 |
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| Components: | This complex has 2 components. |
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| Component 1 |
| Name: | Casein kinase II subunit beta |
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| Synonyms: | CK2N | CSK2B_HUMAN | CSNK2B | Casein kinase II subunit beta | Casein kinase II subunit beta (CK2 beta) | Casein kinase II subunit beta (CK2β) | G5A | Serine/threonine-protein kinase pim-2 |
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| Type: | Enzyme |
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| Mol. Mass.: | 24937.13 |
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| Organism: | Homo sapiens (Human) |
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| Description: | P67870 |
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| Residue: | 215 |
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| Sequence: | MSSSEEVSWISWFCGLRGNEFFCEVDEDYIQDKFNLTGLNEQVPHYRQALDMILDLEPDE
ELEDNPNQSDLIEQAAEMLYGLIHARYILTNRGIAQMLEKYQQGDFGYCPRVYCENQPML
PIGLSDIPGEAMVKLYCPKCMDVYTPKSSRHHHTDGAYFGTGFPHMLFMVHPEYRPKRPA
NQFVPRLYGFKIHPMAYQLQLQAASNFKSPVKTIR
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| Component 2 |
| Name: | Casein kinase II subunit alpha |
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| Synonyms: | CSK21_RAT | Casein Kinase II | Csnk2a1 |
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| Type: | Enzyme Subunit |
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| Mol. Mass.: | 45081.00 |
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| Organism: | Rattus norvegicus (Rat) |
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| Description: | Native CK2 purified from rat liver was used in enzyme phosphorylation assay. |
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| Residue: | 391 |
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| Sequence: | MSGPVPSRARVYTDVNTHRPREYWDYESHVVEWGNQDDYQLVRKLGRGKYSEVFEAINIT
NNEKVVVKILKPVKKKKIKREIKILENLRGGPNIITLADIVKDPVSRTPALVFEHVNNTD
FKQLYQTLTDYDIRFYMYEILKALDYCHSMGIMHRDVKPHNVMIDHEHRKLRLIDWGLAE
FYHPGQEYNVRVASRYFKGPELLVDYQMYDYSLDMWSLGCMLASMIFRKEPFFHGHDNYD
QLVRIAKVLGTEDLYDYIDKYNIELDPRFNDILGRHSRKRWERFVHSENQHLVSPEALDF
LDKLLRYDHQSRLTAREAMEHPYFYTVVKDQARMSSAGMAGGSTPVSSANMMSGISSVPT
PSPLGPLAGSPVIAAANSLGIPVPAAAGAQQ
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| BDBM50466851 |
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| n/a |
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| Name | BDBM50466851 |
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| Synonyms: | CHEMBL4285776 |
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| Type | Small organic molecule |
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| Emp. Form. | C14H10O3 |
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| Mol. Mass. | 226.2274 |
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| SMILES | Cc1cc(=O)oc2cc3cc(O)ccc3cc12 |
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| Structure | 
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