| Reaction Details |
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 | Report a problem with these data |
| Target | Adenosine receptor A1 |
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| Ligand | BDBM50020852 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEBML_28519 |
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| IC50 | 1.8±n/a nM |
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| Citation |  Hamilton, HW; Ortwine, DF; Worth, DF; Bristol, JA Synthesis and structure-activity relationships of pyrazolo[4,3-d]pyrimidin-7-ones as adenosine receptor antagonists. J Med Chem30:91-6 (1987) [PubMed] |
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| More Info.: | Get all data from this article, Assay Method |
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| Adenosine receptor A1 |
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| Name: | Adenosine receptor A1 |
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| Synonyms: | AA1R_RAT | ADENOSINE A1 | ADENOSINE A1 high | ADENOSINE A1 low | Adenosine A1 receptor (A1) | Adenosine receptor | Adenosine receptors A1 | Adora1 |
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| Type: | Protein |
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| Mol. Mass.: | 36704.13 |
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| Organism: | Rattus norvegicus (rat) |
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| Description: | n/a |
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| Residue: | 326 |
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| Sequence: | MPPYISAFQAAYIGIEVLIALVSVPGNVLVIWAVKVNQALRDATFCFIVSLAVADVAVGA
LVIPLAILINIGPQTYFHTCLMVACPVLILTQSSILALLAIAVDRYLRVKIPLRYKTVVT
QRRAAVAIAGCWILSLVVGLTPMFGWNNLSVVEQDWRANGSVGEPVIKCEFEKVISMEYM
VYFNFFVWVLPPLLLMVLIYLEVFYLIRKQLNKKVSASSGDPQKYYGKELKIAKSLALIL
FLFALSWLPLHILNCITLFCPTCQKPSILIYIAIFLTHGNSAMNPIVYAFRIHKFRVTFL
KIWNDHFRCQPKPPIDEDLPEEKAED
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| BDBM50020852 |
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| n/a |
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| Name | BDBM50020852 |
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| Synonyms: | 8-(4-Amino-phenyl)-1,3-dimethyl-3,7-dihydro-purine-2,6-dione | 8-(4-Aminophenyl)theophylline | CHEMBL276830 |
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| Type | Small organic molecule |
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| Emp. Form. | C13H13N5O2 |
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| Mol. Mass. | 271.2746 |
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| SMILES | Cn1c2nc([nH]c2c(=O)n(C)c1=O)-c1ccc(N)cc1 |
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| Structure | 
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