| Reaction Details |
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 | Report a problem with these data |
| Target | Histone-lysine N-methyltransferase NSD2 |
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| Ligand | BDBM50082133 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_1794872 (CHEMBL4266989) |
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| IC50 | 12000±n/a nM |
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| Citation |  Bürli, RW; Wei, H; Ernst, G; Mariga, A; Hardern, IM; Herlihy, K; Cross, AJ; Wesolowski, SS; Chen, H; McKay, RDG; Weinberger, DR; Brandon, NJ; Barrow, JC Novel inhibitors of As(III) S-adenosylmethionine methyltransferase (AS3MT) identified by virtual screening. Bioorg Med Chem Lett28:3231-3235 (2018) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Histone-lysine N-methyltransferase NSD2 |
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| Name: | Histone-lysine N-methyltransferase NSD2 |
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| Synonyms: | KIAA1090 | MMSET | NSD2 | NSD2_HUMAN | Nuclear SET domain-containing protein 2 (NSD2) | TRX5 | WHSC1 |
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| Type: | Protein |
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| Mol. Mass.: | 152327.31 |
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| Organism: | Homo sapiens (Human) |
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| Description: | O96028 |
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| Residue: | 1365 |
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| Sequence: | MEFSIKQSPLSVQSVVKCIKMKQAPEILGSANGKTPSCEVNRECSVFLSKAQLSSSLQEG
VMQKFNGHDALPFIPADKLKDLTSRVFNGEPGAHDAKLRFESQEMKGIGTPPNTTPIKNG
SPEIKLKITKTYMNGKPLFESSICGDSAADVSQSEENGQKPENKARRNRKRSIKYDSLLE
QGLVEAALVSKISSPSDKKIPAKKESCPNTGRDKDHLLKYNVGDLVWSKVSGYPWWPCMV
SADPLLHSYTKLKGQKKSARQYHVQFFGDAPERAWIFEKSLVAFEGEGQFEKLCQESAKQ
APTKAEKIKLLKPISGKLRAQWEMGIVQAEEAASMSVEERKAKFTFLYVGDQLHLNPQVA
KEAGIAAESLGEMAESSGVSEEAAENPKSVREECIPMKRRRRAKLCSSAETLESHPDIGK
STPQKTAEADPRRGVGSPPGRKKTTVSMPRSRKGDAASQFLVFCQKHRDEVVAEHPDASG
EEIEELLRSQWSLLSEKQRARYNTKFALVAPVQAEEDSGNVNGKKRNHTKRIQDPTEDAE
AEDTPRKRLRTDKHSLRKRDTITDKTARTSSYKAMEAASSLKSQAATKNLSDACKPLKKR
NRASTAASSALGFSKSSSPSASLTENEVSDSPGDEPSESPYESADETQTEVSVSSKKSER
GVTAKKEYVCQLCEKPGSLLLCEGPCCGAFHLACLGLSRRPEGRFTCSECASGIHSCFVC
KESKTDVKRCVVTQCGKFYHEACVKKYPLTVFESRGFRCPLHSCVSCHASNPSNPRPSKG
KMMRCVRCPVAYHSGDACLAAGCSVIASNSIICTAHFTARKGKRHHAHVNVSWCFVCSKG
GSLLCCESCPAAFHPDCLNIEMPDGSWFCNDCRAGKKLHFQDIIWVKLGNYRWWPAEVCH
PKNVPPNIQKMKHEIGEFPVFFFGSKDYYWTHQARVFPYMEGDRGSRYQGVRGIGRVFKN
ALQEAEARFREIKLQREARETQESERKPPPYKHIKVNKPYGKVQIYTADISEIPKCNCKP
TDENPCGFDSECLNRMLMFECHPQVCPAGEFCQNQCFTKRQYPETKIIKTDGKGWGLVAK
RDIRKGEFVNEYVGELIDEEECMARIKHAHENDITHFYMLTIDKDRIIDAGPKGNYSRFM
NHSCQPNCETLKWTVNGDTRVGLFAVCDIPAGTELTFNYNLDCLGNEKTVCRCGASNCSG
FLGDRPKTSTTLSSEEKGKKTKKKTRRRRAKGEGKRQSEDECFRCGDGGQLVLCDRKFCT
KAYHLSCLGLGKRPFGKWECPWHHCDVCGKPSTSFCHLCPNSFCKEHQDGTAFSCTPDGR
SYCCEHDLGAASVRSTKTEKPPPEPGKPKGKRRRRRGWRRVTEGK
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| BDBM50082133 |
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| n/a |
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| Name | BDBM50082133 |
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| Synonyms: | CHEMBL3422652 |
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| Type | Small organic molecule |
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| Emp. Form. | C19H19N5O2 |
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| Mol. Mass. | 349.3865 |
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| SMILES | CCn1c(N)c(C#N)c2cc(Oc3ccc(NC(=O)CN)cc3)ccc12 |
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| Structure | 
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