| Reaction Details |
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 | Report a problem with these data |
| Target | Alkaline phosphatase, tissue-nonspecific isozyme |
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| Ligand | BDBM18073 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_1797057 (CHEMBL4269174) |
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| IC50 | >200000±n/a nM |
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| Citation |  Ashraf, A; Ejaz, SA; Rahman, SU; Siddiqui, WA; Arshad, MN; Lecka, J; Sévigny, J; Zayed, MEM; Asiri, AM; Iqbal, J; Hartinger, CG; Hanif, M Hybrid compounds from chalcone and 1,2-benzothiazine pharmacophores as selective inhibitors of alkaline phosphatase isozymes. Eur J Med Chem159:282-291 (2018) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Alkaline phosphatase, tissue-nonspecific isozyme |
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| Name: | Alkaline phosphatase, tissue-nonspecific isozyme |
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| Synonyms: | ALPL | PPBT_HUMAN | tissue-nonspecific alkaline phosphatase precursor |
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| Type: | PROTEIN |
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| Mol. Mass.: | 57306.17 |
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| Organism: | Homo sapiens (Human) |
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| Description: | ChEMBL_1448917 |
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| Residue: | 524 |
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| Sequence: | MISPFLVLAIGTCLTNSLVPEKEKDPKYWRDQAQETLKYALELQKLNTNVAKNVIMFLGD
GMGVSTVTAARILKGQLHHNPGEETRLEMDKFPFVALSKTYNTNAQVPDSAGTATAYLCG
VKANEGTVGVSAATERSRCNTTQGNEVTSILRWAKDAGKSVGIVTTTRVNHATPSAAYAH
SADRDWYSDNEMPPEALSQGCKDIAYQLMHNIRDIDVIMGGGRKYMYPKNKTDVEYESDE
KARGTRLDGLDLVDTWKSFKPRYKHSHFIWNRTELLTLDPHNVDYLLGLFEPGDMQYELN
RNNVTDPSLSEMVVVAIQILRKNPKGFFLLVEGGRIDHGHHEGKAKQALHEAVEMDRAIG
QAGSLTSSEDTLTVVTADHSHVFTFGGYTPRGNSIFGLAPMLSDTDKKPFTAILYGNGPG
YKVVGGERENVSMVDYAHNNYQAQSAVPLRHETHGGEDVAVFSKGPMAHLLHGVHEQNYV
PHVMAYAACIGANLGHCAPASSAGSLAAGPLLLALALYPLSVLF
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| BDBM18073 |
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| n/a |
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| Name | BDBM18073 |
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| Synonyms: | (2S)-2-amino-3-phenylpropanoic acid | CHEMBL301523 | L-[2,3,4,5,6-3H]phenylalanine | L-phenylalanine | Phenylalanine | US11021454, Compound L-phe |
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| Type | Amino Acid |
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| Emp. Form. | C9H11NO2 |
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| Mol. Mass. | 165.1891 |
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| SMILES | N[C@@H](Cc1ccccc1)C(O)=O |
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| Structure | 
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