| Reaction Details |
|---|
 | Report a problem with these data |
| Target | Lanosterol synthase |
|---|
| Ligand | BDBM50467865 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | ChEMBL_1797186 (CHEMBL4269303) |
|---|
| IC50 | 11100±n/a nM |
|---|
| Citation |  Kummari, LK; Butler, MS; Furlong, E; Blundell, R; Nouwens, A; Silva, AB; Kappler, U; Fraser, JA; Kobe, B; Cooper, MA; Robertson, AAB Antifungal benzo[b]thiophene 1,1-dioxide IMPDH inhibitors exhibit pan-assay interference (PAINS) profiles. Bioorg Med Chem26:5408-5419 (2018) [PubMed] Article |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| Lanosterol synthase |
|---|
| Name: | Lanosterol synthase |
|---|
| Synonyms: | 2,3-epoxysqualene--lanosterol cyclase | LSS | LSS_HUMAN | OSC | Oxidosqualene--lanosterol cyclase |
|---|
| Type: | PROTEIN |
|---|
| Mol. Mass.: | 83309.32 |
|---|
| Organism: | Homo sapiens (Human) |
|---|
| Description: | ChEMBL_11231 |
|---|
| Residue: | 732 |
|---|
| Sequence: | MTEGTCLRRRGGPYKTEPATDLGRWRLNCERGRQTWTYLQDERAGREQTGLEAYALGLDT
KNYFKDLPKAHTAFEGALNGMTFYVGLQAEDGHWTGDYGGPLFLLPGLLITCHVARIPLP
AGYREEIVRYLRSVQLPDGGWGLHIEDKSTVFGTALNYVSLRILGVGPDDPDLVRARNIL
HKKGGAVAIPSWGKFWLAVLNVYSWEGLNTLFPEMWLFPDWAPAHPSTLWCHCRQVYLPM
SYCYAVRLSAAEDPLVQSLRQELYVEDFASIDWLAQRNNVAPDELYTPHSWLLRVVYALL
NLYEHHHSAHLRQRAVQKLYEHIVADDRFTKSISIGPISKTINMLVRWYVDGPASTAFQE
HVSRIPDYLWMGLDGMKMQGTNGSQIWDTAFAIQALLEAGGHHRPEFSSCLQKAHEFLRL
SQVPDNPPDYQKYYRQMRKGGFSFSTLDCGWIVSDCTAEALKAVLLLQEKCPHVTEHIPR
ERLCDAVAVLLNMRNPDGGFATYETKRGGHLLELLNPSEVFGDIMIDYTYVECTSAVMQA
LKYFHKRFPEHRAAEIRETLTQGLEFCRRQQRADGSWEGSWGVCFTYGTWFGLEAFACMG
QTYRDGTACAEVSRACDFLLSRQMADGGWGEDFESCEERRYLQSAQSQIHNTCWAMMGLM
AVRHPDIEAQERGVRCLLEKQLPNGDWPQENIAGVFNKSCAISYTSYRNIFPIWALGRFS
QLYPERALAGHP
|
|
|
|---|
| BDBM50467865 |
|---|
| n/a |
|---|
| Name | BDBM50467865 |
|---|
| Synonyms: | CHEMBL4166303 |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C16H9ClN2O3S2 |
|---|
| Mol. Mass. | 376.837 |
|---|
| SMILES | Clc1ccc(cc1)-c1nnc(SC2=CS(=O)(=O)c3ccccc23)o1 |t:13| |
|---|
| Structure | 
|
|---|
Search and Browse
