| Reaction Details |
|---|
 | Report a problem with these data |
| Target | TGF-beta receptor type-1 |
|---|
| Ligand | BDBM50468206 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | ChEMBL_1798382 (CHEMBL4270674) |
|---|
| IC50 | 154±n/a nM |
|---|
| Citation |  ?ezní?ková, E; Tenora, L; Pospí?ilová, P; Galeta, J; Jorda, R; Berka, K; Majer, P; Potá?ek, M; Kry?tof, V ALK5 kinase inhibitory activity and synthesis of 2,3,4-substituted 5,5-dimethyl-5,6-dihydro-4H-pyrrolo[1,2-b]pyrazoles. Eur J Med Chem127:632-642 (2017) [PubMed] Article |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| TGF-beta receptor type-1 |
|---|
| Name: | TGF-beta receptor type-1 |
|---|
| Synonyms: | ALK-5 | ALK5 | Activin A receptor type II-like protein kinase of 53kD | Activin receptor-like kinase 5 | SKR4 | Serine/threonine-protein kinase receptor R4 | TGF-beta receptor type I | TGF-beta type I receptor | TGFBR1 | TGFR-1 | TGFR1_HUMAN | TbetaR-I | Transforming growth factor-beta receptor type I |
|---|
| Type: | enzyme |
|---|
| Mol. Mass.: | 55968.24 |
|---|
| Organism: | Homo sapiens (Human) |
|---|
| Description: | P36897 |
|---|
| Residue: | 503 |
|---|
| Sequence: | MEAAVAAPRPRLLLLVLAAAAAAAAALLPGATALQCFCHLCTKDNFTCVTDGLCFVSVTE
TTDKVIHNSMCIAEIDLIPRDRPFVCAPSSKTGSVTTTYCCNQDHCNKIELPTTVKSSPG
LGPVELAAVIAGPVCFVCISLMLMVYICHNRTVIHHRVPNEEDPSLDRPFISEGTTLKDL
IYDMTTSGSGSGLPLLVQRTIARTIVLQESIGKGRFGEVWRGKWRGEEVAVKIFSSREER
SWFREAEIYQTVMLRHENILGFIAADNKDNGTWTQLWLVSDYHEHGSLFDYLNRYTVTVE
GMIKLALSTASGLAHLHMEIVGTQGKPAIAHRDLKSKNILVKKNGTCCIADLGLAVRHDS
ATDTIDIAPNHRVGTKRYMAPEVLDDSINMKHFESFKRADIYAMGLVFWEIARRCSIGGI
HEDYQLPYYDLVPSDPSVEEMRKVVCEQKLRPNIPNRWQSCEALRVMAKIMRECWYANGA
ARLTALRIKKTLSQLSQQEGIKM
|
|
|
|---|
| BDBM50468206 |
|---|
| n/a |
|---|
| Name | BDBM50468206 |
|---|
| Synonyms: | CHEMBL4291675 |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C26H28N6O2S |
|---|
| Mol. Mass. | 488.605 |
|---|
| SMILES | CC1c2c(c(nn2CC1(C)C)-c1cccc(C)n1)-c1ccnc(Nc2ccc(cc2)S(N)(=O)=O)c1 |
|---|
| Structure | 
|
|---|
Search and Browse
